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Previous neuroimaging studies have found consistent global reductions in global grey matter volume of underweight girls with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>; however, differences in regional grey matter volumes are less consistent. The aims of this study were to investigate grey matter regional volumes of adolescent girls with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> before and after weight recovery and the relationship of any changes with clinical characteristics. We collected high\u2010resolution T1\u2010weighted images from 26 underweight girls with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> before weight gain and 20 healthy control volunteers. Clinical features were assessed using the Eating Disorder Examination Questionnaire. <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> subjects displayed reduced grey matter volumes in the insula, amygdala, prefrontal, hippocampal and cingulate cortices and the precuneus, relative to healthy controls. In a subset of 10 <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> subjects who were followed after weight recovery, grey matter volumes increased to near\u2010control levels in the orbito\u2010 and medial prefrontal, insular, left hippocampal and mid\u2010 and posterior cingulate cortices and precuneus. The recovery of the right anterior thalamus and the left orbitofrontal cortex was correlated with improvements in eating concerns and shape concerns, respectively. However, large parts of the anterior cingulate cortex, caudate nuclei and right hippocampus did not display any grey matter recovery following a short\u2010term of treatment. These results show that in adolescents with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, some brain regions display marked recovery in grey matter volume following weight recovery, whereas others do not, considering grey mater recovery possibly linked to symptom improvement.<\/jats:p>","DOI":"10.1111\/ejn.13659","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T15:02:39Z","timestamp":1503414159000},"page":"2297-2307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Grey matter volume in adolescents with anorexia nervosa and associated eating disorder symptoms"],"prefix":"10.1111","volume":"46","author":[{"given":"Beatriz","family":"Martin Monzon","sequence":"first","affiliation":[{"name":"Translational Health Research Institute (THRI) School of Medicine Western Sydney University Locked Bag 1797, Penrith Sydney NSW 2751 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sloane","family":"Madden","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaughan G.","family":"Macefield","sequence":"additional","affiliation":[{"name":"School of Medicine Western Sydney University Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Touyz","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit School of Psychology University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Kohn","sequence":"additional","affiliation":[{"name":"Centre for Research into Adolescents\u2019 Health (CRASH) Millennium Institute University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Clarke","sequence":"additional","affiliation":[{"name":"Centre for Research into Adolescents\u2019 Health (CRASH) Millennium Institute University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Foroughi","sequence":"additional","affiliation":[{"name":"Translational Health Research Institute (THRI) School of Medicine Western Sydney University Locked Bag 1797, Penrith Sydney NSW 2751 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipa","family":"Hay","sequence":"additional","affiliation":[{"name":"Translational Health Research Institute (THRI) School of Medicine Western Sydney University Locked Bag 1797, Penrith Sydney NSW 2751 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.03.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_78"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0856-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140193"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007033338779"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90023-V"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S73239"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.10.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(00)00058-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199003000-00004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.10.003"},{"key":"e_1_2_11_15_1","first-page":"1869","article-title":"Anterior nucleus of the thalamus","volume":"1","author":"Child D.","year":"2013","journal-title":"Clin Implicat. 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