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We hypothesized that <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> atrophy co\u2010existed with <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> plasticity presenting with increased volume and perfusion in specific regions in the period of post\u2010stroke recovery. Twelve well\u2010recovered stroke patients with pure subcortical lesions in the middle cerebral artery\u2010perfused zone were included. All of them underwent structural and perfusion magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) examinations at admission and a mean of 6\u00a0months after stroke onset. Differences in <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume (<jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content>) on structural images and cerebral blood flow (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>) derived from perfusion images between two examinations were compared using voxel\u2010based morphometry. The associations between changes in <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> with clinical scores were analysed. Decreased <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> was found in post\u2010central gyrus, pre\u2010central gyrus, precuneus, angular gyrus, insula, thalamus and cerebellum, and increased <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> was found in hippocampus, orbital gyrus and lingual gyrus (all corrected <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) at the follow\u2010up examination. Increased <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> was found in subcallosal cingulate gyrus, hippocampus and lingual gyrus (all corrected <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) at the follow\u2010up examination. Only decreased <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> in the anterior lobe of cerebellum was negatively associated with improvement of Barthel index (\u03b2\u00a0=\u00a0\u22120.683, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014). Our study provides the imaging evidence of <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> atrophy co\u2010existing with <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> plasticity involving in increased volume and perfusion in specific regions (including cognition, vision and emotion) in well\u2010recovered stroke patients, which advances our understanding of neurobiology of stroke recovery.<\/jats:p>","DOI":"10.1111\/ejn.13669","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T15:44:19Z","timestamp":1503416659000},"page":"2308-2314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Changes in structure and perfusion of grey matter tissues during recovery from Ischaemic subcortical stroke: a longitudinal <scp>MRI<\/scp> study"],"prefix":"10.1111","volume":"46","author":[{"given":"Xinfeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiology School of Medicine The 2nd Affiliated Hospital of Zhejiang University No.88 Jiefang Road Shangcheng District Hangzhou 310009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine The 2nd Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine The 2nd Affiliated Hospital of Zhejiang University No.88 Jiefang Road Shangcheng District Hangzhou 310009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerfan","family":"Jiaerken","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine The 2nd Affiliated Hospital of Zhejiang University No.88 Jiefang Road Shangcheng District Hangzhou 310009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Advanced Application and Research GE Healthcare Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine The 2nd Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology Henry Ford Health System Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine The 2nd Affiliated Hospital of Zhejiang 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