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These molecules can affect trafficking of AMPARs. The preferential trafficking of calcium\u2010permeable versus impermeable AMPARs can result in disruptions of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and alter cellular functions. In striatal neurodegenerative diseases, changes in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and L\u2010type voltage\u2010gated calcium channels (VGCCs) have been reported. Therefore, this study sought to determine whether a proinflammatory environment alters AMPA\u2010stimulated [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> through calcium\u2010permeable AMPARs and\/or L\u2010type VGCCs in dopamine\u20102\u2010 and dopamine\u20101\u2010expressing striatal spiny projection neurons (D2 and D1 SPNs) in the dorsal striatum. Mice expressing the calcium indicator protein, GCaMP in D2 or D1 SPNs, were utilized for calcium imaging. Microglial activation was assessed by morphology analyses. To induce inflammation, acute mouse striatal slices were incubated with lipopolysaccharide (LPS). Here we report that LPS treatment potentiated AMPA responses only in D2 SPNs. When a nonspecific VGCC blocker was included, we observed a decrease of AMPA\u2010stimulated calcium fluorescence in D2 but not D1 SPNs. The remaining agonist\u2010induced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> was mediated by calcium\u2010permeable AMPARs because the responses were completely blocked by a selective calcium\u2010permeable AMPAR antagonist. We used isradipine, the highly selective L\u2010type VGCC antagonist to determine the role of L\u2010type VGCCs in SPNs treated with LPS. Isradipine decreased AMPA\u2010stimulated responses selectively in D2 SPNs after LPS treatment. Our findings suggest that dorsal striatal D2 SPNs are specifically targeted in proinflammatory conditions and that L\u2010type VGCCs and calcium\u2010permeable AMPARs are important mediators of this effect.<\/jats:p>","DOI":"10.1111\/ejn.13711","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:11:27Z","timestamp":1505743887000},"page":"2519-2533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inflammation alters AMPA\u2010stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-7231","authenticated-orcid":false,"given":"Carissa D.","family":"Winland","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Neuroscience Georgetown University Medical Center Washington D.C. 20007 USA"},{"name":"Department of Neuroscience Georgetown University Medical Center Washington D.C. 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