{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:10:56Z","timestamp":1790395856241,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan","award":["15K08683"],"award-info":[{"award-number":["15K08683"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The dorsal spinal cord, which is essential for somatosensory transmission, comprises a heterogeneous population of neurons with distinct axonal lengths and projection patterns. Although the developmental origin of local\u2010circuit interneurons in the dorsal spinal cord has been well characterized, that of long\u2010range neurons extending axons over a long distance such as supraspinal projection neurons and propriospinal neurons is largely unknown. In this study, we performed birthdate and lineage analyses of these long\u2010range neurons in the mouse dorsal spinal cord. Unilateral injection of a retrograde neuronal tracer, cholera toxin B, into the brain or spinal cord efficiently labeled supraspinal projection neurons localized in Rexed's lamina I and the dorsolateral funiculus (<jats:styled-content style=\"fixed-case\">DLF<\/jats:styled-content>) and long\u2010range propriospinal neurons localized in the <jats:styled-content style=\"fixed-case\">DLF<\/jats:styled-content>, all of which had ipsi\u2010 and contralaterally projecting populations. Most of these neurons were born between E9.5 and E10.5, much earlier than in the case of the neurogenesis of local\u2010circuit neurons. Lineage analysis using an Lbx1\u2010Cre mouse line demonstrated that most long\u2010range neurons were derived from Lbx1\u2010positive neuronal progenitors, except in the case of the contralaterally projecting propriospinal neurons. Characterization of their neurotransmitter identity revealed that almost all of the supraspinal projection neurons were excitatory, whereas the long\u2010range propriospinal neurons comprised both excitatory and inhibitory populations. These results suggest that the supraspinal projection neurons were derived from the early\u2010born <jats:styled-content style=\"fixed-case\">dI<\/jats:styled-content>5 progenitor domain and that the long\u2010range propriospinal ones arose from several early\u2010born progenitor domains.<\/jats:p>","DOI":"10.1111\/ejn.13736","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T19:16:54Z","timestamp":1507144614000},"page":"2608-2619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Developmental origin of long\u2010range neurons in the superficial dorsal spinal cord"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-8441","authenticated-orcid":false,"given":"Kazuhiko","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry Kansai Medical University Shinmachi 2\u20105\u20101 Hirakata Osaka 573\u20101010 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry Kansai Medical University Shinmachi 2\u20105\u20101 Hirakata Osaka 573\u20101010 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22081"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69537-7_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11399"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901390202"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1046-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-4-21"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)90008-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00305-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.08.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<565::AID-CNE5>3.0.CO;2-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.08.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120210"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90495-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1221"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21759"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02167"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068428"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00690-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90204-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901340304"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.046"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079641"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.139592"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10988"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.9.2.47"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91233-X"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00065-3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00689-X"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(90)90157-N"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903280207"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64043-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103321"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.011"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.049"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10249"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000626)422:2<312::AID-CNE11>3.0.CO;2-A"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20356"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901310104"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.03.028"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20134"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901000205"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2225-12.2012"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0717-07.2007"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/5007"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02981.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4690-14.2015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2947"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00950.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249799"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02345"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.07.020"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:18:02Z","timestamp":1696000682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ejn.13736"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13736","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}