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Most likely, metabolic requirements depend upon neuron type, and macroscopic energy demands vary with brain region. However, specific needs of individual neuron types are enigmatic. Therefore, we monitored metabolic activity in the lateral superior olive (<jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content>), an auditory brainstem nucleus containing only one neuron type. <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> neurons exhibit extreme but well\u2010described biophysics with firing rates of several hundred hertz and low input resistances of a few megaohms. We recorded changes in <jats:styled-content style=\"fixed-case\">NADH<\/jats:styled-content> and flavin adenine dinucleotide (<jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content>) autofluorescence and O<jats:sub>2<\/jats:sub> concentration in acute brainstem slices of Mongolian gerbils (<jats:italic>Meriones unguiculatus<\/jats:italic>) following electrical stimulation. The <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> shows the typical biphasic <jats:styled-content style=\"fixed-case\">NADH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> response up to a physiologically relevant frequency of 400\u00a0Hz. In the same animal, we compared the <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> with the hippocampal <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 region and the cerebral cortex. The rate of <jats:styled-content style=\"fixed-case\">NADH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FADH<\/jats:styled-content><jats:sub>2<\/jats:sub> consumption and regeneration was slowest in <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content>. However, frequency dependence was only similar during the consumption phase but varied during regeneration within the three brain regions. Changes in <jats:styled-content style=\"fixed-case\">NADH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FAD<\/jats:styled-content> and O<jats:sub>2<\/jats:sub> levels and blocking metabolic reactions indicate a pronounced contribution of mitochondrial oxidative phosphorylation in the <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> which is known for the other brain regions as well. Lactate transport and interconversion are involved in <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> metabolism as we found in immunohistochemical and pharmacological experiments. Our findings show that the <jats:styled-content style=\"fixed-case\">LSO<\/jats:styled-content> represents an apt, biophysically distinct model for brain metabolism and that neuronal properties determine metabolic needs.<\/jats:p>","DOI":"10.1111\/ejn.13789","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T11:35:57Z","timestamp":1512473757000},"page":"222-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An auditory brainstem nucleus as a model system for neuronal metabolic demands"],"prefix":"10.1111","volume":"47","author":[{"given":"Sonja","family":"Brosel","sequence":"first","affiliation":[{"name":"Department Biology II Division of Neurobiology LMU Munich Gro\u00dfhaderner Str. 2 82152 Planegg\u2010Martinsried Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Grothe","sequence":"additional","affiliation":[{"name":"Department 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