{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:58Z","timestamp":1787014138943,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jack Brockgoff Foundation","award":["3410"],"award-info":[{"award-number":["3410"]}]},{"name":"Dick & Pip Smith Foundation"},{"name":"Australian Postgraduate Award"},{"name":"David Hay Memorial Fund Award"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel\u2010based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty\u2010six individuals with AN and 27 healthy controls underwent a T1\u2010weighted magnetic resonance imaging (MRI) scan. AN participants were found to have reduced grey matter volumes in a number of areas including regions of the basal ganglia (including the ventral striatum), and parietal and temporal cortices. Body mass index (BMI) and global scores on the Eating Disorder Examination Questionnaire (EDE\u2010Q) were also found to correlate with grey matter volumes in a region of the brainstem (including the substantia nigra and ventral tegmental area) in AN, and predicted 56% of the variance in grey matter volumes in this area. The brain regions associated with grey matter reductions in AN are consistent with regions responsible for cognitive deficits associated with the illness including anhedonia, deficits in affect perception and saccadic eye movement abnormalities. Overall, the findings suggest reduced grey matter volumes in AN that are associated with eating disorder symptomatology.<\/jats:p>","DOI":"10.1111\/ejn.13793","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T16:45:32Z","timestamp":1513442732000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differences in regional grey matter volumes in currently ill patients with anorexia nervosa"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6619","authenticated-orcid":false,"given":"Andrea","family":"Phillipou","sequence":"first","affiliation":[{"name":"Department of Optometry &amp; Vision Sciences The University of Melbourne Melbourne VIC Australia"},{"name":"Department of Psychiatry The University of Melbourne Melbourne VIC Australia"},{"name":"Department of Mental Health The Austin Hospital Melbourne VIC Australia"},{"name":"Department of Psychiatry St Vincent's Hospital Melbourne VIC Australia"},{"name":"Centre for Mental Health Swinburne University of Technology John St, Hawthorn Melbourne VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Lee","family":"Rossell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry St Vincent's Hospital Melbourne VIC Australia"},{"name":"Centre for Mental Health Swinburne University of Technology John St, Hawthorn Melbourne VIC 3122 Australia"},{"name":"Monash Alfred Psychiatry Research Centre Monash University &amp; The Alfred Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gurvich","sequence":"additional","affiliation":[{"name":"Monash Alfred Psychiatry Research Centre Monash University &amp; The Alfred Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Jonathan","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Melbourne Melbourne VIC Australia"},{"name":"Department of Psychiatry St Vincent's Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry Allen","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Optometry &amp; Vision Sciences The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Grant","family":"Nibbs","sequence":"additional","affiliation":[{"name":"Centre for Mental Health Swinburne University of Technology John St, Hawthorn Melbourne VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Edward","family":"Hughes","sequence":"additional","affiliation":[{"name":"Centre for Mental Health Swinburne University of Technology John St, Hawthorn Melbourne VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-013-0471-1"},{"key":"e_1_2_10_4_1","first-page":"411","article-title":"Inferior parietal lobule function in spatial perception and visuomotor integration","volume":"52","author":"Andersen R.A.","year":"2011","journal-title":"Compr. 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