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The neuropathogenesis of AD is suggested to be a result of the accumulation of amyloid\u2010\u03b2 (A\u03b2) peptides in the brain. To date, A\u03b2\u2010induced cognitive and neurophysiologic impairments have not been illuminated sufficiently. Therefore, we aimed to examine how spontaneous brain activities of rats changed by injection of increasing A\u03b2 doses into the brain hemispheres, and whether these changes could be used as a new biomarker for the early diagnosis of the AD. Rats were randomized into following groups: sham (Sham) and seven A\u03b2\u2010treated (i.c.v.) groups in increasing concentrations (from A\u03b2\u20101 to A\u03b2\u20107). After recovery, EEG recordings were obtained from implanted electrodes from eight electrode locations, and then, spectral and statistical analyses were performed. A significant decrement in gamma activity was observed in all A\u03b2 groups compared with the sham group. In delta activity, we observed significant changes from A\u03b2\u20104 to A\u03b2\u20107 group compared with sham group. Delta coherence values were decreased from A\u03b2\u20104 to A\u03b2\u20107 and A\u03b2\u20105 to A\u03b2\u20107 groups for frontal and temporal electrode pairs, respectively. A gradual increment was observed in A\u03b2<jats:sub>1\u201042<\/jats:sub> level till A\u03b2\u20104 group. Positive correlation for global delta power and negative correlation for global gamma power between A\u03b2<jats:sub>1\u201042<\/jats:sub> peptide levels were detected. Consequently, it is conceivable to suggest gamma oscillation might be used to detect early stages of AD. Moreover, changes in delta activity provide information about the onset of major pathologic changes in the progress of AD.<\/jats:p>","DOI":"10.1111\/ejn.13832","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:53:42Z","timestamp":1516640022000},"page":"1013-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Alterations in spontaneous delta and gamma activity might provide clues to detect changes induced by amyloid\u2010\u03b2 administration"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-1209","authenticated-orcid":false,"given":"Enis","family":"Hidisoglu","sequence":"first","affiliation":[{"name":"Department of Biophysics Akdeniz University Faculty of Medicine Dumlupinar Boulevard TR\u201007058 Campus Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Kantar\u2010Gok","sequence":"additional","affiliation":[{"name":"Department of Biophysics Akdeniz University Faculty of Medicine Dumlupinar Boulevard TR\u201007058 Campus Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Er","sequence":"additional","affiliation":[{"name":"Department of Biophysics Akdeniz University Faculty of Medicine Dumlupinar Boulevard TR\u201007058 Campus Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alev Duygu","family":"Acun","sequence":"additional","affiliation":[{"name":"Department of Biophysics Akdeniz University Faculty of Medicine Dumlupinar Boulevard TR\u201007058 Campus Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piraye","family":"Yargicoglu","sequence":"additional","affiliation":[{"name":"Department of Biophysics Akdeniz University Faculty of Medicine Dumlupinar Boulevard TR\u201007058 Campus Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05601.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100066"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-010-8141-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4122-11.2012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-460X(82)90204-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540040011008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00132-X"},{"key":"e_1_2_10_13_1","first-page":"100","article-title":"New trends in clinical electroencephalography","volume":"217","author":"Bickford R.G.","year":"1976","journal-title":"Practitioner"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0731-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00388.1998"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2012.675327"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.07.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3233\/JAD-2010-100267","article-title":"Conversion of elderly to Alzheimer's dementia: role of confluence of hypothermia and senescent stigmata \u2010 the plausible pathway","volume":"21","author":"Daulatzai M.A.","year":"2010","journal-title":"J. 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