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For example, cross\u2010modal sensory processing at the level of the occipital cortex appears to be associated with adaptive behaviors in the blind. However, detailed studies examining the structural properties of key white matter pathways in other regions of the brain remain limited. Given that blind individuals rely heavily on their sense of hearing, we examined the structural properties of two important pathways involved with auditory processing, namely the uncinate and arcuate fasciculi. High angular resolution diffusion imaging (<jats:styled-content style=\"fixed-case\">HARDI<\/jats:styled-content>) tractography was used to examine structural parameters (i.e., tract volume and quantitative anisotropy, or <jats:styled-content style=\"fixed-case\">QA<\/jats:styled-content>) of these two fasciculi in a sample of 13 early blind individuals and 14 normally sighted controls. Compared to controls, early blind individuals showed a significant increase in the volume of the left uncinate fasciculus. A small area of increased <jats:styled-content style=\"fixed-case\">QA<\/jats:styled-content> was also observed halfway along the right arcuate fasciculus in the blind group. These findings contribute to our knowledge regarding the broad neuroplastic changes associated with profound early blindness.<\/jats:p>","DOI":"10.1111\/ejn.13848","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T04:56:44Z","timestamp":1517288204000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early blindness is associated with increased volume of the uncinate fasciculus"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-4657","authenticated-orcid":false,"given":"Corinna M.","family":"Bauer","sequence":"first","affiliation":[{"name":"Laboratory for Visual Neuroplasticity Department of Ophthalmology Massachusetts Eye and Ear Infirmary Harvard Medical School 20 Staniford Street Boston MA 02114 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