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Recent studies have revealed that the <jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content>, in addition to the <jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content>, plays important roles in the development and expression of cocaine\u2010induced addiction and stress\u2010induced enhancement of addictive behaviors. Additionally, neuroplasticity induced in <jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content> cholinergic neurons by repeated cocaine administration critically contributes to these behaviors. Elucidation of the underlying mechanisms of cocaine\u2010induced neuroplasticity in the <jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content> that influences reward circuit activity may lead to the development of therapeutic strategies to treat cocaine addiction and stress\u2010induced reinstatement of cocaine use. This review summarizes recent progress in the study of the <jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content>, specifically neuroplasticity in <jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content> cholinergic neurons induced by cocaine and its functional roles in the development and modulation of addictive behaviors associated with cocaine.<\/jats:p>","DOI":"10.1111\/ejn.13962","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T14:06:37Z","timestamp":1527084397000},"page":"2239-2246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus contributes to the development of cocaine 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