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Previous studies have shown that dysfunction in the <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content> has been associated with several disorders, including depression and cardiovascular diseases. In this manuscript, we aimed to investigate how gender and the treatment with a serotonin selective reuptake inhibitor (<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>) could affect mitochondrial bioenergetics and oxidative stress in the brainstem of male and female rats. Fluoxetine, our chosen <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>, was used during the neonatal period (i.e., from postnatal Day 1 to postnatal Day 21\u2014<jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>1 to <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>21) in both male and female animals. Thereafter, experiments were conducted in adult rats (60\u00a0days old). 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