{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:56Z","timestamp":1787014136277,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Amsterdam Brain and Mind Project"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite apparent sex differences in the development and treatment of alcohol use disorder, relatively little is known about the underlying neural mechanisms. In this study, we therefore investigated neural cue\u2010reactivity in a sample of male (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a028) and female (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a027) problem drinkers (matched on age and alcohol use severity) with an average alcohol use disorder identification test score of 12 which is indicative of a likely alcohol use disorder. Neural cue\u2010reactivity data were extracted from four regions of interest: the ventral and dorsal striatum and the ventral and dorsal anterior cingulate cortex, with a significance level set at\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05. While the cue\u2010reactivity paradigm induced similar levels of self\u2010reported craving in men and women, visual alcohol cues induced significantly stronger striatal activation in men compared to drinkers. While sex differences in ventral striatal cue\u2010reactivity were partly explained by sex differences in alcohol intake, cannabis use, negative affect and anxiety, this was not the case for sex differences in dorsal striatal cue\u2010reactivity. These results suggest that alcohol cues are differentially processed by men and women and that the neurobiological mechanisms behind cue\u2010reactivity differ between the sexes. Consequently, paradigms using alcohol\u2010related pictures may not be optimal to induce cue\u2010reactivity in female drinkers and may not be optimal to measure neurobiological markers of alcohol use severity and relapse. Future alcohol cue\u2010reactivity studies should, in addition to including both men and women, include different types of cues (e.g., stressors and imagery in addition to pictures) to assess sex differences in alcohol cue\u2010reactivity.\n                  <\/jats:p>","DOI":"10.1111\/ejn.13991","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T08:03:57Z","timestamp":1528704237000},"page":"2264-2273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Striatal alcohol cue\u2010reactivity is stronger in male than female problem drinkers"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-5758","authenticated-orcid":false,"given":"Anne Marije","family":"Kaag","sequence":"first","affiliation":[{"name":"Addiction Development and Psychopathology (ADAPT) Lab Department of Psychology University of Amsterdam Amsterdam the Netherlands"},{"name":"Amsterdam Brain and Cognition University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Psychiatry Academic Medical Center University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Anatomy and Neurosciences Amsterdam Neuroscience VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout W.","family":"Wiers","sequence":"additional","affiliation":[{"name":"Addiction Development and Psychopathology (ADAPT) Lab Department of Psychology University of Amsterdam Amsterdam the Netherlands"},{"name":"Amsterdam Brain and Cognition University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taco J.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences Amsterdam Neuroscience VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Pattij","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences Amsterdam Neuroscience VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Goudriaan","sequence":"additional","affiliation":[{"name":"Amsterdam Brain and Cognition University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Psychiatry Academic Medical Center University of Amsterdam Amsterdam the Netherlands"},{"name":"Arkin Mental Health Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0959523031000154454"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2017.02.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.09.027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.01.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12383"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23963"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Berman A. 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