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The reasons for the variability in response to such experiences are not clear but may relate to pre\u2010existing individual differences that influence their downstream effects. Applying structural magnetic resonance imaging (\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    ) to a rat model of abnormal aggression induced by peripubertal stress, we examined whether individual differences in the development of an aggressive phenotype following stress exposure were underpinned by variation in the structure of aggression\u2010associated, corticolimbic brain regions. We also assessed whether responsiveness of the hypothalamic\u2013pituitary\u2013adrenal axis to stress was associated with neurobehavioural outcome following adversity. A subset of the rats exposed to peripubertal stress developed an aggressive phenotype, while the remaining rats were affected in other behavioural domains, such as increased anxiety\u2010like behaviours and reduced sociability. Peripubertal stress led to changes in tissue microstructure within prefrontal cortex, amygdala and hippocampal formation\n                    <jats:italic>only<\/jats:italic>\n                    in those individuals displaying an aggressive phenotype. Attenuated glucocorticoid response to stress during juvenility predicted the subsequent development of an aggressive phenotype in peripubertal stress\u2010exposed rats. Our study establishes a link between peripubertal stress exposure in rats and structural deviations in brain regions linked to abnormal aggression and points towards low glucocorticoid responsiveness to stress as a potential underlying mechanism. We additionally highlight the importance of considering individual differences in behavioural response to stress when determining neurobiological correlates.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14061","type":"journal-article","created":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T21:29:26Z","timestamp":1530480566000},"page":"1818-1832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress"],"prefix":"10.1111","volume":"48","author":[{"given":"Sophie E.","family":"Walker","sequence":"first","affiliation":[{"name":"Laboratory of Behavioral Genetics Brain Mind Institute School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias C.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Cash","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C. 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