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However, the population of <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>\u2010expressing cells affected in neuropathic conditions or underlying the antiallodynic activity of antidepressants remains unknown. Using a mouse line in which <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content> receptors were selectively ablated in cells expressing Nav1.8 sodium channels (<jats:styled-content style=\"fixed-case\">DOP cKO<\/jats:styled-content>), we established that these <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content> peripheral receptors were mandatory for duloxetine to alleviate mechanical allodynia in a neuropathic pain model based on sciatic nerve cuffing. We then examined the impact of nerve cuffing and duloxetine treatment on <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>\u2010positive populations using a knock\u2010in mouse line expressing a fluorescent version of the <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content> receptor fused with the enhanced green fluorescent protein (<jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>). Eight weeks postsurgery, we observed a reduced proportion of <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>\u2010positive small peptidergic sensory neurons (calcitonin gene\u2010related peptide (<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>) positive) in dorsal root ganglia and a lower density of <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>\u2010positive free nerve endings in the skin. These changes were not present in nerve\u2010injured mice chronically treated with oral duloxetine. In addition, increased <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content> translocation to the plasma membrane was observed in neuropathic conditions but not in duloxetine\u2010treated neuropathic mice, which may represent an additional level of control of the neuronal activity by <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content> receptors. Our results therefore established a parallel between changes in the expression profile of peripheral <jats:styled-content style=\"fixed-case\">DOP<\/jats:styled-content> receptors and mechanical allodynia induced by sciatic nerve cuffing.<\/jats:p>","DOI":"10.1111\/ejn.14093","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T14:49:12Z","timestamp":1532962152000},"page":"2231-2246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain"],"prefix":"10.1111","volume":"48","author":[{"given":"Rhian Alice","family":"Ceredig","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique Institut des Neurosciences Cellulaires et Int\u00e9gratives Universit\u00e9 de Strasbourg  Strasbourg 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