{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:17:34Z","timestamp":1787851054221,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008487","name":"Cure Parkinson\u2019s Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Exenatide, a glucagon\u2010like peptide\u20101 agonist and a licensed treatment for Type 2 diabetes significantly reduced deterioration in motor symptoms in patients with Parkinson's disease in a randomized, placebo\u2010controlled trial. In addition, there were trends favouring the exenatide group in assessments of nonmotor symptoms, cognition, and quality of life. The aim of this exploratory post hoc analysis was to generate new hypotheses regarding (a) whether candidate baseline factors might predict the magnitude of response to exenatide; and (b) whether the beneficial effects of exenatide reported for the overall population are consistent in various subgroups of patients. Univariate and multivariate analyses were conducted to determine possible predictors of motor response to exenatide in this cohort. Potential treatment by subgroup interactions for changes in; motor severity, nonmotor symptoms, cognition, and quality of life after 48\u2010weeks treatment with exenatide were evaluated among post hoc subgroups defined by age, motor phenotype, disease duration, disease severity, body mass index (\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    ), and insulin resistance. In the subgroup analyses, exenatide once\u2010weekly was associated with broadly improved outcome measures assessing motor severity, nonmotor symptoms, cognition, and quality of life across all subgroups, however, tremor\u2010dominant phenotype and lower Movement Disorder Society\u2010Sponsored Revision of the Unified Parkinson's Disease Rating Scale (\n                    <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>\n                    ) Part\u20102 scores predicted greatest motor response to exenatide and there was an indication that patients with older age of onset and disease duration over 10\u00a0years responded less well. While patients with a range of demographic and clinical factors can potentially benefit from exenatide once\u2010weekly, these data support an emphasis towards recruiting patients at earlier disease in future planned clinical trials of gluacagon\u2010like peptide\u20101 (\n                    <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                    \u20101) receptor agonists in Parkinson's disease (\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ).\n                  <\/jats:p>","DOI":"10.1111\/ejn.14096","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T23:33:28Z","timestamp":1533598408000},"page":"410-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Post hoc analysis of the Exenatide\u2010\n                    <scp>PD<\/scp>\n                    trial\u2014Factors that predict response"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8594-2483","authenticated-orcid":false,"given":"Dilan","family":"Athauda","sequence":"first","affiliation":[{"name":"Sobell Department of Motor Neuroscience UCL Institute of Neurology &amp; 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