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We have characterized cytotoxic damage to the retina of adult zebrafish caused by the injection of cobalt chloride (CoCl\n                    <jats:sub>2<\/jats:sub>\n                    ) into the vitreous cavity. The CoCl\n                    <jats:sub>2<\/jats:sub>\n                    concentration we used primarily caused injury to photoreceptors. We observed the complete disappearance of cones, followed by rods, across the retina surface from 28 to 96\u00a0hr after CoCl\n                    <jats:sub>2<\/jats:sub>\n                    injury. The loss of 30% of bipolar cells was also observed by 50\u00a0hr after lesion (hpl). CoCl\n                    <jats:sub>2<\/jats:sub>\n                    injury provoked a strong induction of the proliferative activity of multipotent M\u00fcller glia and derived progenitors. The effect of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    on retina cells was significantly reduced by treatment with glutamate ionotropic receptor antagonists. Cone photoreceptor regeneration occurred 25\u00a0days after injury. Moreover, a single dose of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    induced vascular damage and regeneration, whereas three injections of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    administered weekly provoked neovascular\u2010like changes 20\u00a0days after injury. CoCl\n                    <jats:sub>2<\/jats:sub>\n                    injury also caused microglial reactivity in the optic disc, retina periphery and fibre layer. CoCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced damage enhanced pluripotency and proneural transcription factor gene expression in the mature retina 72 hpl. Tumour necrosis factor alpha, vascular endothelial growth factor (\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    ) and\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    receptor\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    levels were also significantly enhanced by 72 hpl. The injury paradigm we have described in this work may be useful for the discovery of signalling molecules and pathways that participate in the regenerative response and it may serve as a model to screen for compounds that could potentially treat aberrant angiogenesis.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14113","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T11:48:32Z","timestamp":1534160912000},"page":"3019-3042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of proliferative, glial and angiogenic responses after a CoCl\n                    <sub>2<\/sub>\n                    \u2010induced injury of photoreceptor cells in the adult zebrafish retina"],"prefix":"10.1111","volume":"48","author":[{"given":"Matias Pedro","family":"Medrano","sequence":"first","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Pisera Fuster","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Antonio","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Paez","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon Oscar","family":"Bernabeu","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"},{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad de Buenos Aires (UBA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9230-8138","authenticated-orcid":false,"given":"Maria Paula","family":"Faillace","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Prof. Bernardo Houssay (IFIBIO\u2010Houssay) UBA y Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"},{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad de Buenos Aires (UBA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40139-017-0127-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12627"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.144700"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.05.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06352.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00166-09"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1145503"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.149"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-07-0617"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00056"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90162-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10821"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-28"},{"key":"e_1_2_10_15_1","first-page":"617","article-title":"Segmentation and classification of cell cycle phases in fluorescence imaging. 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