{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:28Z","timestamp":1790776408855,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selective attention is a basic process required to maintain goal\u2010directed behavior by appropriately responding to target stimuli and suppressing reactions to non\u2010target stimuli. It has been proposed that auditory selective attention is linked to the activity of the locus coeruleus\u2010norepinergic (LC\u2010NE) system and a large\u2010scale fronto\u2010parietal cortical network, but there is still sparse causal evidence for these assumptions. By applying transcutaneous vagal nerve stimulation (tVNS) and transcranial random noise stimulation (tRNS) over the frontal cortex, we systematically assessed the involvement of these subcortical and cortical components in the regulation of auditory selective attention. Using a single\u2010blinded, sham\u2010controlled, within\u2010subject design we analyzed online effects of tVNS and tRNS in 20 healthy participants during an auditory oddball paradigm. We show significant stimulation\u2010dependent modulations of auditory selective attention on the behavioral and electrophysiological level. Compared to sham, tVNS increased the P3 amplitude, while tRNS reduced the reaction time to target stimuli. Moreover, both techniques reduced the P3 latency. Our data provide evidence for the functional relevance of the subcortical NE system in the regulation of neural resources that allows a phasic response to incoming target stimuli. They indicate that frontal cortex structures are crucially involved in the successful evaluation of the respective information. Moreover, our results are in favor of the LC\u2010P3 hypothesis claiming the vital role of the NE system in auditory selective attention and in the generation of the P3. Of note, the effects of tVNS on auditory selective attention are comparable with those evoked by pharmacological interventions and invasive vagal nerve stimulation.<\/jats:p>","DOI":"10.1111\/ejn.14128","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:40:53Z","timestamp":1535118053000},"page":"2301-2309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Modulating auditory selective attention by non\u2010invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-1171","authenticated-orcid":false,"given":"Katharina S.","family":"Rufener","sequence":"first","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Geyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Janitzky","sequence":"additional","affiliation":[{"name":"Department of Neurology Krankenhaus St. Elisabeth Damme Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Jochen","family":"Heinze","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino","family":"Zaehle","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3616807"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135709"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00140-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(00)00142-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.11.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12544"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.185"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0272-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.037"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2002-11.2011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8760(95)00028-Q"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.02.023"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.10.051"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.09.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90206-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2013.01.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(84)90016-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0048577201990559"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00070"},{"key":"e_1_2_11_24_1","first-page":"102","article-title":"Transcutaneous Vagal Nerve Stimulation (tVNS): A new neuromodulation tool in healthy humans?","volume":"6","author":"Leusden J. W. R.","year":"2015","journal-title":"Frontiers in Psychology"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.016"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00367"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2011.11.004"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.4.510"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2010.01057.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199210000-00002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-01-00081.1989"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.019"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(95)05130-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00162"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.03.021"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.01.034"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00851"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2392679"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3820343"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03212388"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.03.015"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(98)00141-9"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0839"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4248-08.2008"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3920147"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2013.00158"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.11.175"},{"key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.55782\/ane-2008-1702","article-title":"The auditory P3 from passive and active three\u2010stimulus oddball paradigm","volume":"68","author":"Wronka E.","year":"2008","journal-title":"Acta Neurobiologiae Experimentalis"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.14128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.14128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:46:00Z","timestamp":1720539960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/ejn.14128"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14128","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}