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Drug\u2010related memory depends on persistent changes in dopamine\u2010glutamate interactions in the medial prefrontal cortex (<jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content>), basolateral amygdala, nucleus accumbens core and hippocampus. Recent evidence from our laboratory indicated that the cerebellum is also a relevant node for drug\u2010cue associations. In the present study, we tested the role that specific regions of the cerebellum and <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content> play in the acquisition of cocaine\u2010induced preference conditioning. Quinolinic acid was used to manage a permanent deactivation of lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> in the vermis prior to conditioning. Additionally, lidocaine was infused into the prelimbic and infralimbic (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>) cortices for reversible deactivation before every training session. The present findings show, for the first time, that the cerebellum and <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content> might act together in order to acquire drug\u2010cue Pavlovian associations. Either a dorsal lesion in lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> or an <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content> deactivation encouraged cocaine\u2010induced preference conditioning. Moreover, simultaneous <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u2010cerebellar deactivation prevented the effect of either of the separate deactivations. Therefore, similar to the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content> cortex, neural activity in the cerebellum may be crucial for ensuring inhibitory control of the expression of cocaine\u2010related memories.<\/jats:p>","DOI":"10.1111\/ejn.14187","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T03:50:05Z","timestamp":1538538605000},"page":"2613-2622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The role of the cerebellum in drug\u2010cue associative memory: functional interactions with the medial prefrontal cortex"],"prefix":"10.1111","volume":"50","author":[{"given":"Isis","family":"Gil\u2010Miravet","sequence":"first","affiliation":[{"name":"\u00c1rea de Psicobiolog\u00eda Universitat Jaume I Castell\u00f3n de la Plana 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