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Changes in the glutamatergic system seem to play a role in the effects of social defeat stress on the rewarding properties of cocaine and amphetamine. The aim of the present study was to evaluate the involvement of <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate (<jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>) and \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazolepropionic acid (<jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content>) glutamate receptors in the effects of social defeat on the conditioned place preference induced by 3,4\u2010methylenedioxymethamphetamine (<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>). Our hypothesis was that changes in these receptors could mediate the effects of social defeat on <jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content> reward. Young adult male mice were exposed to an episode of social defeat with an aggressive conspecific immediately before each conditioning session with <jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content> (1.25\u00a0mg\/kg, four sessions on alternating days). According to the treatment received before defeats, six groups were used: saline, 5 or 10\u00a0mg\/kg of memantine (<jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content> antagonist) and 0.25, 1 or 5\u00a0mg\/kg of 6\u2010cyano\u20107\u2010nitroquinoxaline\u20102,3\u2010dione (<jats:styled-content style=\"fixed-case\">CNQX<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content> antagonist). One control group was exposed to exploration before place conditioning. In two additional defeated and control groups, the membrane expression of <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content> receptors was determined in the striatum and the hippocampus. Control and memantine\u2010treated groups developed place preference, but not defeated mice treated with saline or <jats:styled-content style=\"fixed-case\">CNQX<\/jats:styled-content>, suggesting that the blockade of <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content> receptors reversed the effects of social defeat. Social defeat decreased the expression of several subunits of <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content> receptors, mainly GluN1 and GluA1. These results demonstrated that glutamatergic plasticity is involved in the effects of social defeat stress on <jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content> reward.<\/jats:p>","DOI":"10.1111\/ejn.14190","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T01:06:28Z","timestamp":1538442388000},"page":"2623-2634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of <scp>NMDA<\/scp> and <scp>AMPA<\/scp> glutamatergic receptors in the effects of social defeat on the rewarding properties of <scp>MDMA<\/scp> in mice"],"prefix":"10.1111","volume":"50","author":[{"given":"M. P.","family":"Garc\u00eda\u2010Pardo","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Psicobiolog\u00eda de las Drogodependencias Departamento de Psicobiolog\u00eda Facultad de Psicolog\u00eda Universidad de Valencia Avda. Blasco Ib\u00e1\u00f1ez, 21 46010 Valencia Spain"},{"name":"Unitat Predepartamental de Medicina Facultat de Ci\u00e8ncies de la Salut Universitat Jaume I. Castell\u00f3 de la Plana Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mi\u00f1arro","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Psicobiolog\u00eda de las Drogodependencias Departamento de Psicobiolog\u00eda Facultad de Psicolog\u00eda Universidad de Valencia Avda. 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