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The aim of this study was to tackle the role of a frontal cortical region, the dorsolateral prefrontal cortex (dl<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>). To this end, we stimulated the cortical site corresponding to the left dl<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content> with transcranial direct current stimulation (<jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>) during a placebo procedure and measured any change in the motor placebo effect in all the participants and more specifically in placebo\u2010responders. Three different experiments were conducted in which healthy volunteers performed a force motor task with the index finger. The placebo treatment consisted of transcutaneous electrical nerve stimulation (<jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>). In Experiment 1 (expectation alone), participants were only verbally suggested about the positive effects of <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>. In Experiment 2 (expectation and conditioning), participants were verbally suggested about <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> and conditioned with a surreptitious increase in a visual feedback of force. In Experiment 3 (control procedure), participants were told that <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> was inefficient. Each participant was tested in three different days with anodal, cathodal and sham <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the dl<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>. Results showed that in Experiment 1 and 2 force increased after the procedure, independently of <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>. By focusing on placebo\u2010responders, we found that in Experiment 1 force remained stable after active <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>, whereas it increased after inactive <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>. These findings bring new evidence on the neural underpinnings of the motor placebo effect, by showing that independently of the polarity, active <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the left dl<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content> may undermine the expectation\u2010induced enhancement of force in placebo\u2010responders.<\/jats:p>","DOI":"10.1111\/ejn.14217","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T06:57:04Z","timestamp":1540537024000},"page":"3410-3425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of the dorsolateral prefrontal cortex in the motor placebo effect"],"prefix":"10.1111","volume":"48","author":[{"given":"Bernardo","family":"Villa\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  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