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Mild <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">mTBI<\/jats:styled-content>) are the most prevalent and can lead to a range of neurobehavioral problems, including substance abuse. A single blast exposure, inducing <jats:styled-content style=\"fixed-case\">mTBI<\/jats:styled-content> alters the medial prefrontal cortex, an area implicated in addiction, for at least 30\u00a0days post injury in rats. Repeated blast exposures result in greater physiological and behavioral dysfunction than single exposure; however, the impact of repeated <jats:styled-content style=\"fixed-case\">mTBI<\/jats:styled-content> on addiction is unknown. In this study, the effect of <jats:styled-content style=\"fixed-case\">mTBI<\/jats:styled-content> on various stages of oxycodone use was examined. Male Sprague Dawley rats were exposed to a blast model of <jats:styled-content style=\"fixed-case\">mTBI<\/jats:styled-content> once per day for 3\u00a0days. Rats were trained to self\u2010administer oxycodone during short (2\u00a0h) and long (6\u00a0h) access sessions. Following abstinence, rats underwent extinction and two cued reinstatement sessions. Sham and rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content> rats had similar oxycodone intake, extinction responding and cued reinstatement of drug seeking. A second group of rats were trained to self\u2010administer oxycodone with varying reinforcement schedules (fixed ratio (<jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>)\u20102 and <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>\u20104). Under an <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>\u20102 schedule, rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>\u2010exposed rats earned fewer reinforcers than sham\u2010exposed rats. During 10 extinction sessions, the rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>\u2010exposed rats exhibited significantly more seeking for oxycodone than the sham\u2010injured rats. There was a positive correlation between total oxycodone intake and day 1 extinction drug seeking in sham, but not in rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>\u2010exposed rats. Together, this suggests that rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>\u2010exposed rats are more sensitive to oxycodone\u2010associated cues during reinstatement than sham\u2010exposed rats and that rb<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content> may disrupt the relationship between oxycodone intake and seeking.<\/jats:p>","DOI":"10.1111\/ejn.14281","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T08:05:20Z","timestamp":1542701120000},"page":"2101-2112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Repeated blast model of mild traumatic brain injury alters oxycodone self\u2010administration and drug seeking"],"prefix":"10.1111","volume":"50","author":[{"given":"Natalie N.","family":"Nawarawong","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee WI 53226 USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Slaker","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee WI 53226 USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Muelbl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee WI 53226 USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA"},{"name":"Clement J. Zablocki Veterans Affairs Medical Center Milwaukee WI USA"},{"name":"Joint Department of Biomedical Engineering Marquette University Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Chiariello","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA"},{"name":"Clement J. 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