{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:59:22Z","timestamp":1782550762515,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sensorineural hearing loss is often accompanied by difficulties with understanding speech in fluctuating backgrounds, suggesting that neural coding of complex sound features, such as the sound envelope, is impaired. Here, we studied how temporal and rate coding of the envelope is affected in the inferior colliculus immediately after acoustic trauma. Neural activity in response to amplitude\u2010modulated noise was recorded from the inferior colliculus of the guinea pig, before and immediately after a 1\u2010hr 11\u2010<jats:styled-content style=\"fixed-case\">kH<\/jats:styled-content>z acoustic trauma. Units with a characteristic frequency (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) below the trauma frequency (&lt;11\u00a0kHz) showed increased response gains, a measure for temporal coding of the sound envelope, especially at low modulation frequencies (\u2264128\u00a0Hz). Units with a <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\u00a0&gt;\u00a011\u00a0kHz, which had large acoustic trauma\u2010induced threshold shifts, had decreased response gains to amplitude\u2010modulated noise. Shapes of temporal modulation transfer functions shifted toward a higher proportion of low\u2010pass shapes in low\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> units, and to less band\u2010pass shapes in high\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> units. Furthermore, driven firing rates decreased, especially at high modulation frequencies for high\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> units. The observed changes occurred immediately following trauma and were thus a result of the immediate trauma\u2010induced damage to the auditory system. If also present in human subjects, reduced response gains in high\u2010frequency units could disrupt coding of consonants and consequently impair speech understanding in noisy environments. Moreover, the enhanced temporal coding by low\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> units of the low modulation frequencies could overly amplify responses to low\u2010frequency noise, further deteriorating listening in noise.<\/jats:p>","DOI":"10.1111\/ejn.14299","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T13:35:45Z","timestamp":1544794545000},"page":"1220-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neural coding of the sound envelope is changed in the inferior colliculus immediately following acoustic trauma"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-0581","authenticated-orcid":false,"given":"Amarins N.","family":"Heeringa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioural and Cognitive Neurosciences) University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioural and Cognitive Neurosciences) University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3405-12.2013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.404209"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07280.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-008-0142-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-018-0669-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2451-05.2005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4608-11.2012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07183.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00027-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00708.2007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1452740"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2014.03.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.10.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00776.2003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3944-15.2016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00872.2009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-010-0223-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00119-1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.255"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2015.00014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.60.6.1799"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607364103"},{"key":"e_1_2_10_25_1","volume-title":"Directional statistics","author":"Mardia K. V.","year":"2000"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00034.2004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2722-16.2017"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-008-0143-x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1385177"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22644"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00776.2006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23152"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5832-11.2012"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00139.2003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01098.2015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116981109"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90205-F"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.10.021"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1579009"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.397851"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-04-01057.1991"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(90)90049-U"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.303"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0357-04.2004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3615-14.2015"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-27083-3_1"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0208-09.2009"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2013.11.006"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:49:32Z","timestamp":1694364572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/ejn.14299"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14299","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"assertion":[{"value":"2018-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}