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These similarities have been recognized in the DSM\u20105, although several relevant differences still exist in the diagnostic criteria, in particular, with regard to the role of cue\u2010 and stress\u2010 induced craving. Craving, recently included as a new criterion for SUDs diagnosis only, is a key construct also in the pathophysiology of GD. Furthermore, brain imaging studies indicate that similar alterations in cortico\u2010limbic\u2010striatal and prefrontal control circuits underlie the emergence of craving states in both disorders. This has important implications for the identification of neurobiologically based anti\u2010craving interventions, which may be used for both GD and SUDs. In this regard, a novel neuromodulation intervention, named repetitive transcranial magnetic stimulation (rTMS), is emerging as a promising treatment for craving in SUDs, and could potentially be effective also in treating gambling urges. Here, we review the clinical neurobiological research on GD, with a specific emphasis on the neural circuits implicated in cue\u2010 and stress\u2010craving, taking SUDs as the major comparative example. Furthermore, we describe the studies that have evaluated rTMS as a therapeutic tool for targeting and restoring the neural alterations underlying gambling urge. The manuscript concludes discussing some of the limitations of the current studies, and suggests directions for future rTMS research in GD.<\/jats:p>","DOI":"10.1111\/ejn.14313","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T20:41:51Z","timestamp":1545424911000},"page":"2370-2383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neural correlates of cue\u2010 and stress\u2010induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-2701","authenticated-orcid":false,"given":"Primavera A.","family":"Spagnolo","sequence":"first","affiliation":[{"name":"Human Motor Control Section National Institute on Neurological Disorders and Stroke National Institutes of Health 10 Center Drive Room I3471:10CRC Bethesda MD 20892\u20109412 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"G\u00f3mez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Novella Fronda Foundation for Studies and Applied Clinical Research in the Field of Addiction Medicine Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Terraneo","sequence":"additional","affiliation":[{"name":"Novella Fronda Foundation for Studies and Applied Clinical Research in the Field of Addiction Medicine Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Gallimberti","sequence":"additional","affiliation":[{"name":"Novella Fronda Foundation for Studies and Applied Clinical Research in the Field of Addiction Medicine Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Bonci","sequence":"additional","affiliation":[{"name":"Intramural Research Program National Institute on Drug Abuse US National Institutes of Health Baltimore MD USA"},{"name":"Solomon H. 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