{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:40:43Z","timestamp":1790163643272,"version":"4.1.0"},"reference-count":124,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006392","name":"Centre Hospitalier Universitaire Vaudois","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adolescence is a tumultuous period in the lifetime of an individual confronted to major changes in emotional, social and cognitive appraisal. During this period of questioning and doubt, while the executive functions are still maturing, the abstract reasoning remains vague and the response inhibition loose; ultimately the adolescent scarcely resists temptation. Consequently, adolescence is often associated with uninhibited risk\u2010taking, reckless behaviours, among which are alcohol and illicit drugs use. Here, we discuss how the development of the prefrontal cortex (which critically contributes to rational decision\u2010making and temporal processing of complex events) can be associated with the idiosyncratic adolescent behaviour, and potentially uncontrolled alcohol use. Most importantly, we present clinical and preclinical evidence supporting that ethanol exposure has deleterious effects on the adolescent developing brain. Ultimately, we discuss why a late maturing prefrontal cortex represents a ripe candidate to environmental influences that contribute to shape the adolescent brain but, potentially, can also trigger lifelong maladaptive responses, including increased vulnerability to develop substance use disorder later in life.<\/jats:p>","DOI":"10.1111\/ejn.14316","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T16:19:10Z","timestamp":1545841150000},"page":"2274-2281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Prefrontal cortex development and emergence of self\u2010regulatory competence: the two cardinal features of adolescence disrupted in context of alcohol abuse"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-8335","authenticated-orcid":false,"given":"Kshitij S.","family":"Jadhav","sequence":"first","affiliation":[{"name":"Laboratory on the Neurobiology of Addictive and Eating Disorders Center for Psychiatric Neuroscience Department of Psychiatry Lausanne University Hospital Site de Cery CH\u20101008 Prilly Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-759X","authenticated-orcid":false,"given":"Benjamin","family":"Boutrel","sequence":"additional","affiliation":[{"name":"Laboratory on the Neurobiology of Addictive and Eating Disorders Center for Psychiatric Neuroscience Department of Psychiatry Lausanne University Hospital Site de Cery CH\u20101008 Prilly Switzerland"},{"name":"Division of Adolescent and Child Psychiatry Department of Psychiatry Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.10.046"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(10)91009-X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.119"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.039"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.09.009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.54.5.317"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4087"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0895-11.2011"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.03.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.07.003"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902860306"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1584"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00043.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.10.1014"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81056-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00118"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4789-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80374-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12530"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579416000766"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3587-14.2015"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2012.00069"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022835107795"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2015.11.018"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.01.013"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721413480170"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12353"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.3.444"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3483-8"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2010.01035.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3645-09.2009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.5.2.117"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00au37672"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.08.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.11.020"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4560-6"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3313"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01879.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2008.06.013"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096380"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.08.015"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21909"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900730106"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5216-08.2009"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.11.004"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1579"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149987"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0078-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024190429920"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.41.4.625"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066893"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.11.007"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116523109"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.009"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/13158"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.01.003"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1642"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13697"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2010.01081.x"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.40.6.1148"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0256-y"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.4.334"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121251109"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.110"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.05.023"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21716"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1747"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08780.2000"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.044"},{"key":"e_1_2_12_76_1","unstructured":"Lipari R.N. &Jean\u2010Francois B.(2013)A day in the life of college students aged 18 to 22: substance use facts.The CB HSQ ReportSubstance Abuse and Mental Health Services Administration (US) Rockville (MD) pp.1\u20137."},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.02.014"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/35084005"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2004.00745.x"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2012.03.028"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5651-12.2013"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-014-9651-0"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0606-11.2011"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2538"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.09.002"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(02)00012-X"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1168-0"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301554"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3080-12.2012"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:osobl\/9780199552917.001.0001"},{"key":"e_1_2_12_91_1","first-page":"947","article-title":"Why do many psychiatric disorders emerge during adolescence? Nature reviews","volume":"9","author":"Paus T.","year":"2008","journal-title":"Neuroscience"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105108108"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.07.002"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-1006.2006.00026.x"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2004.09.016"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.07.007"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)90610-6"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5471.1656"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/0044118X16688708"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.031"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1401.001"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033814"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2994"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1982.0082"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10030385"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb01961.x"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0436"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00014-2"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00145"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2014.02.005"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004269900007"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04235"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45758-0_254"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.030"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.190"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2003.09.028"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902410302"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3189-13.2014"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.07.002"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18533"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21525"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.08.001"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00307"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1871-2"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.14316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.14316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:05:37Z","timestamp":1694289937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/ejn.14316"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14316","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]},"assertion":[{"value":"2018-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}