{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:55:56Z","timestamp":1769597756107,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) is a progressive neurodegenerative disorder caused by the loss of dopamine, an important neurotransmitter involved in regulating movement. Nuclear medicine imaging methods such as single\u2010photon emission computed tomography (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>) combined with radiotracers can obtain the density of this neurotransmitter. This reduced density leads to classic <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> symptoms, such as bradykinesia, tremor and stiffness, consequently affecting walking and postural control. The aim of this study was to verify the correlation between disorders of gait kinematics and postural instability with dopamine depletion in individuals with mild to moderate <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. This is a descriptive, observational cross\u2010sectional study. Subjects were assessed for spatiotemporal gait parameters by a three\u2010dimensional motion capture system, for postural control by stabilometry on a force plate. Dopamine depletion was verified through 99mTc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101 (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) examination. The subjects were in the off\u2010stage of levodopa in all analysis. We evaluated 71 individuals, 32 with mild to moderate <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HY<\/jats:styled-content> 2 and 2.5) and 39 healthy individuals matched for gender, age, and height. There was a significant difference between the groups regarding the spatiotemporal variables of gait, as well as in the stabilometric variables. However, there was no correlation between these disturbances and the uptake values of 99mTc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101. The results indicate that there is no correlation between gait impairments and postural instability of individuals with mild to moderate <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and the dopaminergic depletion measured through the 99mTc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101 (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>).<\/jats:p>","DOI":"10.1111\/ejn.14328","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T16:09:47Z","timestamp":1545926987000},"page":"1640-1648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impairments in gait kinematics and postural control may not correlate with dopamine transporter depletion in individuals with mild to moderate Parkinson's disease"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-9398","authenticated-orcid":false,"given":"Maria Eduarda Parcianello","family":"Cabeleira","sequence":"first","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Rehabilitation Sciences  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Souza","family":"Pagnussat","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Rehabilitation Sciences  Porto Alegre Brazil"},{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Health Sciences  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Severo","family":"do Pinho","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre 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Roberto","family":"de Mello Rieder","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Rehabilitation Sciences  Porto Alegre Brazil"},{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Health Sciences  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Palermo","family":"Schifino","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Rehabilitation Sciences  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Henrique Tieppo","family":"Fornari","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre Post\u2010Graduation Program in Rehabilitation Sciences  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neivo da 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