{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:47:25Z","timestamp":1782517645226,"version":"3.54.5"},"reference-count":100,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Government of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    For more than three decades it has been known, that striatal neurons become hyperactive after the loss of dopamine input, but the involvement of dopamine (\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    ) D1\u2010 or D2\u2010receptor\u2010expressing neurons has only been demonstrated indirectly. By recording neuronal activity using fluorescent calcium indicators in D1 or D2\n                    <jats:styled-content style=\"fixed-case\">eGFP<\/jats:styled-content>\n                    \u2010expressing mice, we showed that following dopamine depletion, both types of striatal output neurons are involved in the large increase in neuronal activity generating a characteristic cell assembly of particular neurons that dominate the pattern. When we expressed channelrhodopsin in all the output neurons, light activation in freely moving animals, caused turning like that following dopamine loss. However, if the light stimulation was patterned in pulses the animals circled in the other direction. To explore the neuronal participation during this stimulation we infected normal mice with channelrhodopsin and calcium indicator in striatal output neurons. In slices made from these animals, continuous light stimulation for 15\u00a0s induced many cells to be active together and a particular dominant group of neurons, whereas light in patterned pulses activated fewer cells in more variable groups. These results suggest that the simultaneous activity of a large dominant group of striatal output neurons is intimately associated with parkinsonian symptoms.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14344","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T12:21:45Z","timestamp":1547209305000},"page":"1512-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine\u2010depleted mice"],"prefix":"10.1111","volume":"49","author":[{"given":"Omar","family":"J\u00e1idar","sequence":"first","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Carrillo\u2010Reid","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta Gisselle","family":"Lopez\u2010Huerta","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Hernandez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-8163","authenticated-orcid":false,"given":"Jos\u00e9","family":"Bargas","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianela","family":"Garcia\u2010Munoz","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-8362","authenticated-orcid":false,"given":"Gordon William","family":"Arbuthnott","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_10_4_1","first-page":"121P","article-title":"Spontaneous activity of single units in the striatum after unilateral destruction of the dopamine input","volume":"239","author":"Arbuthnott G. W.","year":"1974","journal-title":"Journal of Physiology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2402638"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.2.507"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/3477.678624"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00295.2016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1559"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.07.028.2009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.2.433"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3226-11.2011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065715500264"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90975.2008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01131.2007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-070816-033647"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7730"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01614"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90843-X"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11846"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00382.2013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25457"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1632"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1840-08.2008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1527-09.2009"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(82)90082-X"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00015"},{"key":"e_1_2_10_31_1","first-page":"15","article-title":"Different corticostriatal integration in spiny projection neurons from direct and indirect pathways","volume":"4","author":"Flores\u2010Barrera E.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_10_32_1","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin K. B. J.","year":"2008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1278-13.2013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90409-5"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2147780"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113641"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91217-6"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2842-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.08.022"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-26-08931.2003"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01481"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)91047-6"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.5772\/21036"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1380-10.2010"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3632"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01496-1"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237018"},{"issue":"1171","key":"e_1_2_10_48_1","first-page":"e1177","article-title":"The spatiotemporal organization of the striatum encodes action space","volume":"95","author":"Klaus A.","year":"2017","journal-title":"Neuron"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09159"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.1.0053"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.010"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0156-16.2016"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/4\/045002"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11028"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2693-17.2018"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4721-12.2013"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1000-4"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90041-2"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00518-9"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406077111"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1098-2396"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021840504342"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2000.01346.x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.185"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.4.1800"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91481-2"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02463.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.032"},{"key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0022-3565(25)28745-6","article-title":"Spontaneous activity of the putamen after chronic interruption of the dopaminergic pathway: Effect of L\u2010dopa","volume":"175","author":"Ohye C.","year":"1970","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.008"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)00671-S"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1098-2396"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.31887\/DCNS.2016.18.1\/kparker","article-title":"Optogenetic approaches to evaluate striatal function in animal models of Parkinson disease","volume":"18","author":"Parker K. L.","year":"2016","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0090-6"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.02.023"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5139-09.2010"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0753-07.2007"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1239073"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00475-7"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2323"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90202-8"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108480"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4514-06.2007"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-2312(02)00838-X"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(82)90015-6"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238057"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80993-9"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0658-17.2017"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160575"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1250-9"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.095"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw263"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5493-07.2008"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703813104"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.032"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6145-08.2009"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90187-3"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.036"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.10.013"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050696"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.10.030"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.14344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.14344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:12:48Z","timestamp":1782515568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":100,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/ejn.14344"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14344","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,30]]},"assertion":[{"value":"2018-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}