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Glucocorticoids regulate the function of serotonergic neurons in the dorsal raphe nucleus (<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>), which are the major source of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> to the forebrain. <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> neurons are electrophysiologically heterogeneous, though whether this phenotypic variation aligns with specific brain functions or neuropsychiatric disease states is largely unknown. The goal of this work was to determine if chronic exogenous glucocorticoid administration differentially affects the electrophysiological profile of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> neurons implicated in the regulation of emotion versus visual sensation by comparing properties of cells projecting to medial prefrontal cortex (<jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content>) versus lateral geniculate nucleus (<jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content>). Following retrograde tracer injection into <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content>, male Sprague\u2010Dawley rats received daily injections of corticosterone (<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>) for 21\u00a0days, after which whole\u2010cell patch clamp recordings were made from retrogradely labeled <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> neurons. <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>\u2010treatment significantly increased the action potential half\u2010width of <jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content>\u2010projecting <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> neurons, but did not significantly affect the firing frequency or excitatory postsynaptic currents of these cells. <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>\u2010treatment significantly reduced the input resistance, evoked firing frequency, and spontaneous excitatory postsynaptic current frequency of <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content>\u2010projecting <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> neurons, indicating a concurrent reduction of both intrinsic excitability and excitatory drive. Our results suggest that the serotonergic regulation of cognitive and emotional networks in the <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content> may be more sensitive to the effects of glucocorticoid excess than visual sensory circuits in the <jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content> and that reduced 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> transmission in the <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content> may underlie the association between glucocorticoid excess and depression.<\/jats:p>","DOI":"10.1111\/ejn.14355","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T08:04:26Z","timestamp":1548662666000},"page":"1712-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selective vulnerability of dorsal raphe\u2010medial prefrontal cortex projection neurons to corticosterone\u2010induced hypofunction"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-6544","authenticated-orcid":false,"given":"Eric W.","family":"Prouty","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-4307","authenticated-orcid":false,"given":"Daniel J.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Rowan University School of Osteopathic Medicine Stratford New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry D.","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Rowan University School of Osteopathic Medicine Stratford New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24027"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn300224n"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.09.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.10.032"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8472-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.11.005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385870-2.00010-X"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2383-13.2013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"Chrousos G. 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