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Previous research suggests that <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> dynamics may be altered in Huntington's disease, which could be of paramount relevance to intrathecal drug delivery to the brain. To test this hypothesis, we conducted a prospective cross\u2010sectional study comparing people with early stage Huntington's disease with age\u2010 and gender\u2010matched healthy controls. <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> peak velocity, mean velocity and mean flow at the level of the cerebral aqueduct, and sub\u2010arachnoid space in the upper and lower spine, were quantified using phase contrast <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. We calculated Spearman's rank correlations, and tested inter\u2010group differences with Wilcoxon rank\u2010sum test. Ten people with early Huntington's disease, and 10 controls were included. None of the quantified measures was associated with potential modifiers of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> dynamics (demographics, osmolality, and brain volumes), or by known modifiers of Huntington's disease (age and <jats:italic>HTT<\/jats:italic><jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat length); and no significant differences were found between the two studied groups. While external validation is required, the attained results are sufficient to conclude tentatively that a clinically relevant alteration of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> dynamics \u2013 that is, one that would justify dose\u2010adjustments of intrathecal drugs \u2013 is unlikely to exist in Huntington's disease.<\/jats:p>","DOI":"10.1111\/ejn.14356","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T08:08:27Z","timestamp":1548662907000},"page":"1632-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast <scp>MRI<\/scp>"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-7938","authenticated-orcid":false,"given":"Filipe B.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"UCL Huntington's Disease Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Byrne","sequence":"additional","affiliation":[{"name":"UCL Huntington's Disease Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"De Vita","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology University College London  London UK"},{"name":"Department of Biomedical Engineering School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileanoir B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"UCL Huntington's Disease Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola Z.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Ixico Plc  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael I.","family":"Scahill","sequence":"additional","affiliation":[{"name":"UCL Huntington's Disease Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[{"name":"UCL Huntington's Disease Centre UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-11-10"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21788-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat7108"},{"key":"e_1_2_10_6_1","unstructured":"CHDI Foundation(2012).Enroll\u2010HD: A prospective registry study in a Global Huntington's Disease Cohort. 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