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These circadian rhythm alterations are more pronounced in age\u2010associated neurodegenerative disorders such as Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), in which they often precede the onset of other symptoms by many years. As well as their early onset, the findings that fragmentation of daily rest\u2010activity rhythms in non\u2010demented older subjects is associated earlier cognitive decline, increased risk of incident <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, and preclinical <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> neuropathology, suggest that circadian rhythm disruption may contribute to the development and progression of the neuropathological changes occurring in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Conversely, other studies have implicated amyloid\u2010beta, a prominent neurotoxin that accumulates in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, in the impairment of circadian rhythms. Thus, circadian rhythm disruption and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010associated neurodegeneration may interact to form a deleterious cycle. This article reviews the neural and molecular mechanisms underlying the age\u2010 and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010related changes in circadian rhythms. It also explores therapeutic strategies proposed to ameliorate circadian rhythm deficits in elderly and demented individuals.<\/jats:p>","DOI":"10.1111\/ejn.14358","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T21:51:25Z","timestamp":1548712285000},"page":"310-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Interacting influences of aging and Alzheimer's disease on circadian rhythms"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-9016","authenticated-orcid":false,"given":"Marilyn J.","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Kentucky Medical School  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2225-05.2005"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02890-6"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.1.26"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2016.11.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.03.051"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014523107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403253840"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4696-04.2005"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00145-5"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1419"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.11.001"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00285-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1496-12.2012"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01182-1"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.1.40"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(04)90014-2"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.6.M303"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326238"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.09.021"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2005.00462.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3821-05.2005"},{"issue":"2","key":"e_1_2_13_23_1","first-page":"e0028","article-title":"Suprachiasmatic nucleus interaction with the arcuate nucleus: Essential for organizing physiological rhythms","volume":"42","author":"Buijs F. 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