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Moreover, we found differential expression of growth factors in SOD1<jats:sup>G93A<\/jats:sup> mice, with distinct regulation patterns of FGF\u20102 in spinal cord and muscle tissue. Within the present study we aimed to characterize FGF\u20102\u2010isoform specific effects on survival, motor performance as well as gene expression patterns predominantly in muscle tissue by generating double mutant SOD1<jats:sup>G93A<\/jats:sup>FGF\u20102 high molecular weight\u2010 and SOD1<jats:sup>G93A<\/jats:sup>FGF\u20102 low molecular weight\u2010knockout mice. While isoform specific depletion was not beneficial regarding survival or motor performance of double mutant mice, we found isoform\u2010dependent differential gene expression of epidermal growth factor (EGF) in the muscle of SOD1<jats:sup>G93A<\/jats:sup>FGF\u20102 low molecular weight knockout mice compared to single mutant SOD1<jats:sup>G93A<\/jats:sup> mice. This significant downregulation of EGF in the muscle tissue of double mutant SOD1<jats:sup>G93A<\/jats:sup>FGF\u20102 low molecular weight knockout mice implies that FGF\u20102 low molecular weight knockout (or the presence of the FGF\u20102 high molecular weight isoform) selectively impacts EGF gene expression in ALS muscle tissue.<\/jats:p>","DOI":"10.1111\/ejn.14405","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T08:17:28Z","timestamp":1552983448000},"page":"3028-3045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isoform\u2010selective as opposed to complete depletion of fibroblast growth factor 2 (FGF\u20102) has no major impact on survival and gene expression in SOD1<sup>G93A<\/sup> amyotrophic lateral sclerosis 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