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Our objective in the present study was to examine the effects of the pan\u2010T\u2010type calcium channel blocker Z944 on the acquisition, consolidation and extinction of conditioned fear in <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and the non\u2010epileptic control (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>) strain. Z944 (10\u00a0mg\/kg; ip) was administered 15\u00a0min prior to either acquisition, extinction day 1 (24\u00a0hr later), acquisition and extinction day 1, or during the consolidation (post\u2010acquisition) of tone\u2010cued fear conditioning. Extinction was examined 24 and 48\u00a0hr after conditioning. In drug na\u00efve <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content>, increased freezing during the acquisition and extinction phases of fear conditioning was found. Short\u2010term effects of Z944 on performance were observed as Z944 increased freezing during testing on the day it was administered. Z944 administered prior to the acquisition phase had a long\u2010term effect on extinction. Specifically, both <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s showed a decrease in freezing during extinction relative to drug na\u00efve <jats:styled-content style=\"fixed-case\">GAERS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content> rats respectively. Regardless of strain or treatment, female rats showed reduced extinction of fear relative to male rats. These results demonstrate that T\u2010type calcium channels contribute to the neural systems that mediate the learning and memory of conditioned fear. Overall, these findings suggest that T\u2010type calcium channel blockers show promise in the treatment of learning impairments observed in disorders such as CAE.<\/jats:p>","DOI":"10.1111\/ejn.14406","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T04:01:05Z","timestamp":1553054465000},"page":"3046-3059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The T\u2010type calcium channel blocker Z944 reduces conditioned fear in Genetic Absence Epilepsy Rats from Strasbourg and the non\u2010epileptic control strain"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-0016","authenticated-orcid":false,"given":"Wendie N.","family":"Marks","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology, and Pharmacology University of Saskatchewan Saskatoon Saskatchewan 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