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The mechanisms underlying cannabinoid\u2010based drugs effects are not fully known but given the neuro\u2010modulatory functions of the endocannabinoid system, it seems likely that agonistic activity at the cannabinoid type\u20101 receptors (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content><jats:sub>1<\/jats:sub>) might modulate the functions of other neurotransmitter systems. The present review has summarized the currently available pre\u2010clinical and clinical data on the interactions of <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content><jats:sub>1<\/jats:sub> and cannabinoid type\u20102 receptors (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content><jats:sub>2<\/jats:sub>) with the central neurotransmitters; dopamine, serotonin, noradrenaline, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>, glutamate and opioids. Acute and chronic exposures to cannabinoids exert pharmacological alterations in the mammalian brain that have profound implications for our understanding of the neuropharmacology of cannabinoid\u2010based drugs and their effects on mental health and the brain. A recent emergence uses of cannabis for medical purpose together with legalization and decriminalization of cannabis and increasing use of highly potent synthetic cannabinoids raise a growing concern over the effects of cannabinoids and their interaction with other neurotransmitters on physical and mental health.<\/jats:p>","DOI":"10.1111\/ejn.14407","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T18:47:50Z","timestamp":1552934870000},"page":"2322-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Modulatory effects of cannabinoids on brain neurotransmission"],"prefix":"10.1111","volume":"50","author":[{"given":"Koby","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Behavioral Science Ariel University Science Park 40700 Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[{"name":"Research Unit Geha Mental Health Center Petah Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science Ariel University Science Park 40700 Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.02.014"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00403-9"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00967-0"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.07.016"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.07.014"},{"issue":"5","key":"e_1_2_15_7_1","first-page":"279","article-title":"Systematic review of safeness and therapeutic efficacy of cannabis in patients with multiple sclerosis, neuropathic pain, and in oncological patients treated with chemotherapy","volume":"41","author":"Amato L.","year":"2017","journal-title":"Epidemiol. 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