{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:08:47Z","timestamp":1789992527290,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["scholarship"],"award-info":[{"award-number":["scholarship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq grant 142264\/2014\u20108"],"award-info":[{"award-number":["CNPq grant 142264\/2014\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Grooming behaviour has different functions on many species during development and can be observed and affected during periods of stress. By selecting male mice with high (HI) and low (LI) immobility traits in the tail suspension test, a screening for antidepressant drugs, we investigate how these phenotypes associated with grooming behaviour may be influenced by the effects of repeated restraint stress. For this we used the sucrose preference test and the splash test in a novel and a familiar cage performed before and after exposure to 2\u00a0days of restraint stress. Animals were submitted to an additional day of restraint stress before the hypothalamus, prefrontal cortex and midbrain extraction for dopamine activity analysis. Corticosterone analysis was made in three distinct moments: without stress (prior first restraint session), immediately after the last restrain, and 1\u00a0hr after the last restrain episode. Compared to LI group, HI animals exhibited an increased frequency and decreased time of grooming in the familiar cage. In the novel cage, stress increased frequency and time of grooming of HI animals compared to LI. Corticosterone levels were increased in HI animals after 3\u00a0days of stress. Lower hypothalamic dopaminergic activity without stress and decreased hypothalamic dopaminergic activity immediately after stress in HI group were observed. The HI group displayed decreased prefrontal cortex dopaminergic activity and increased activity in the mesolimbic area. We proposed that through the influence of stress the two phenotypes manifested as a resilient (LI) and a not resilient (HI) trait in response to restraint stress.<\/jats:p>","DOI":"10.1111\/ejn.14409","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T03:52:48Z","timestamp":1553053968000},"page":"2942-2954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test"],"prefix":"10.1111","volume":"50","author":[{"given":"Thiago M.","family":"Reis\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Behaviour, Institute of Psychology University of S\u00e3o Paulo Sao Paulo Brazil"},{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"},{"name":"Post\u2010Graduate Program of Environmental and Experimental Pathology and Post\u2010Graduate Program of Dentistry Paulista University Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaisa M.","family":"Sandini","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilio S.","family":"Calefi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna C. G.","family":"Orlando","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Environmental and Experimental Pathology and Post\u2010Graduate Program of Dentistry Paulista University Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula N.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge C.","family":"Florio","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle G. T.","family":"Queiroz\u2010Hazarbassanov","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-9416","authenticated-orcid":false,"given":"Maria Martha","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behaviour, Institute of Psychology University of S\u00e3o Paulo Sao Paulo Brazil"},{"name":"Department of Pathology, School of Veterinary Medicine University of S\u00e3o Paulo Sao Paulo Brazil"},{"name":"Post\u2010Graduate Program of Environmental and Experimental Pathology and Post\u2010Graduate Program of Dentistry Paulista University Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.07.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26014-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2648"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.10.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0045421"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20261"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0810as55"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2003.5.3\/dcharney"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/foc.2.3.368"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32935"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(79)92563-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02352-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.05.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90069-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1822"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(96)00008-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.85.327"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(75)90103-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179191"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2010.11.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.01.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.10.019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415191111"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01976.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90274-D"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-02-00676.2001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(79)90362-5"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90271-0"},{"key":"e_1_2_9_32_1","unstructured":"Kalueff A. V.(2000).\u201cMeasuring Grooming in Stress and Comfort.\u201dProceedings of Measuring Behaviour 3rd International Conference on Methods and Techniques in Behavioral Research. 148\u201349. Nijmegen The Netherlands: 3rd International Conference on Methods and Techniques in Behavioral Research."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.10.001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677060590949683"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511676109"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.8"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22169"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(79)90043-0"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579412000715"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.013"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(98)00018-9"},{"issue":"4","key":"e_1_2_9_42_1","first-page":"1131","article-title":"\u201cEvidence That a Single Exposure to Aversive Stimuli Triggers Long\u2010Lasting Effects in the Hypothalamus\u2010Pituitary\u2010Adrenal Axis That Consolidate with Time\u201d","volume":"20","author":"Mart\u00ed O.","year":"2001","journal-title":"European Journal of Neuroscience"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01568.2000"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.116.3.263"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2011.00039"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00494-2"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.09.004"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.02.068"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90574-Y"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3234"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb38591.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.09.014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013871407464"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.201"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-303-9_2"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.143948"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v5.25338"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.3.825"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428203"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(87)90002-9"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.67"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120050"},{"issue":"6","key":"e_1_2_9_64_1","first-page":"259268","article-title":"Short\u2010term social isolation induces depressive\u2010like behaviour and reinstates the retrieval of an aversive task: Mood\u2010congruent memory in male mice?","volume":"37","author":"Taktsu\u2010Coleman A. L.","year":"2012","journal-title":"Journal of Psychiatry & Neuroscience"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.052"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/263242a0"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.08.013"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.03.006"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2647"},{"issue":"2","key":"e_1_2_9_70_1","first-page":"191","article-title":"Grooming behavior in Diplura (Insecta: Apterygota)","volume":"85","author":"Valentine Barry D.","year":"1978","journal-title":"Psyche (New York)"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1037\/pne0000038"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1026"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.14409","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:17:31Z","timestamp":1694197051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/ejn.14409"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14409","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"2018-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}