{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:48:29Z","timestamp":1784616509600,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23500383"],"award-info":[{"award-number":["JP23500383"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26430011"],"award-info":[{"award-number":["JP26430011"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Feedback regulation from the higher association areas is thought to control the primary sensory cortex, contribute to the cortical processing of sensory information, and work for higher cognitive functions such as multimodal integration and attentional control. However, little is known about the underlying neural mechanisms. Here, we show that the posterior parietal cortex (<jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content>) persistently inhibits the activity of the primary visual cortex (V1) in mice. Activation of the <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> causes the suppression of visual responses in V1 and induces the short\u2010term depression, which is specific to visual stimuli. In contrast, pharmacological inactivation of the <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> or disconnection of cortical pathways from the <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> to V1 results in an effect of transient enhancement of visual responses in V1. Two\u2010photon calcium imaging demonstrated that the cortical disconnection caused V1 excitatory neurons an enhancement of visual responses and a reduction of orientation selectivity index (<jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content>). These results show that the <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> regulates the response properties of V1 excitatory neurons. Our findings reveal one of the functions of the <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content>, which may contribute to higher brain functions in mice.<\/jats:p>","DOI":"10.1111\/ejn.14424","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T09:50:42Z","timestamp":1556013042000},"page":"2970-2987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Feedback inhibition derived from the posterior parietal cortex regulates the neural properties of the mouse visual cortex"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-4127","authenticated-orcid":false,"given":"Ryuichi","family":"Hishida","sequence":"first","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"},{"name":"Division of Neurobiology and Anatomy Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tsukano","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manavu","family":"Tohmi","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yoshitake","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Meguro","sequence":"additional","affiliation":[{"name":"Division of Neurobiology and Anatomy Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohide","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Division of Neurobiology and Anatomy Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchio","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Genetic and Behavioral Neuroscience Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuei","family":"Shibuki","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.03.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.07.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.01.026.2008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20164"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.021"},{"key":"e_1_2_10_9_1","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin K. B. J.","year":"2008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.12.2.193"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2434-06.2006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3476"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13764"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00426.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10918"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2014.07.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.08.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01091-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.11.056"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01356-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3043-15.2016"},{"key":"e_1_2_10_22_1","first-page":"42","article-title":"Where the eye looks, the hand follows; limb\u2010dependent magnetic misreaching in optic ataxia","volume":"5","author":"Jackson S. R.","year":"2005","journal-title":"Current Biology"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00270.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01657-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20284"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4061"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.11.012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-02-00768.1993"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003770"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10835"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2909-15.2016"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00919.2013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.01223"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90364-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227280"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.08.010"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12204"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12417"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.040709"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4641-06.2007"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.006"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10905"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.12.025"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.01.061"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05926.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903150207"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10757"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0089-16.2016"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21286"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.09.010"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00146"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.006"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254126"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.14424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.14424","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.14424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:17:35Z","timestamp":1694197055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/ejn.14424"],"URL":"https:\/\/doi.org\/10.1111\/ejn.14424","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"2018-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}