{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:06:41Z","timestamp":1778908001168,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Grey matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) volume alterations have been repeatedly demonstrated in patients with first episode psychosis (<jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>). Some of these neuroanatomical abnormalities are already evident in the at\u2010risk mental state (<jats:styled-content style=\"fixed-case\">ARMS<\/jats:styled-content>) for psychosis. Not only <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> alterations but also neurocognitive impairments predate the onset of frank psychosis with verbal learning and memory (<jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content>) being among the most impaired domains. Yet, their interconnection with alterations in <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes remains ambiguous. Thus, we evaluated associations of different subcortical <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes in the medial temporal lobe with <jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content> performance in antipsychotic\u2010na\u00efve <jats:styled-content style=\"fixed-case\">ARMS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> patients. Data from 59 <jats:styled-content style=\"fixed-case\">ARMS<\/jats:styled-content> and 31 <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> patients, collected within the prospective Fr\u00fcherkennung von Psychosen study, were analysed. Structural T1\u2010weighted images were acquired using a 3 Tesla magnetic resonance imaging scanner. <jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content> was assessed using the California Verbal Learning Test and its factors Attention Span, Learning Efficiency, Delayed Memory and Inaccurate Memory. <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> patients showed significantly enlarged volumes of hippocampus, pallidum, putamen and thalamus compared to <jats:styled-content style=\"fixed-case\">ARMS<\/jats:styled-content> patients. A significant negative association between amygdala and pallidum volume and Attention Span was found in <jats:styled-content style=\"fixed-case\">ARMS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> patients combined, which however did not withstand correction for multiple testing. Although we found significant between\u2010group differences in subcortical volumes and <jats:styled-content style=\"fixed-case\">VLM<\/jats:styled-content> is among the most impaired cognitive domains in emerging psychosis, we could not demonstrate an association between low performance and subcortical <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes alterations in antipsychotic\u2010na\u00efve patients. Hence, deficits in this domain do not appear to stem from alterations in subcortical structures.<\/jats:p>","DOI":"10.1111\/ejn.14427","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T09:48:46Z","timestamp":1556012926000},"page":"3060-3071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No associations between medial temporal lobe volumes and verbal learning\/memory in emerging psychosis"],"prefix":"10.1111","volume":"50","author":[{"given":"Laura","family":"Egloff","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"},{"name":"Division of Clinical Psychology and Epidemiology Department of Psychology University of Basel Basel Switzerland"},{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lenz","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Studerus","sequence":"additional","affiliation":[{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Heitz","sequence":"additional","affiliation":[{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Harrisberger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Smieskova","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Leanza","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology and Epidemiology Department of Psychology University of Basel Basel Switzerland"},{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Andreou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"},{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Borgwardt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-8789","authenticated-orcid":false,"given":"Anita","family":"Riecher\u2010R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Center for Gender Research and Early Detection University of Basel Psychiatric Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2003.12.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22124"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.12.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs095"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.08.009"},{"key":"e_1_2_11_8_1","volume-title":"Confirmatory factor analysis for applied research","author":"Brown T. 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