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Converging evidence from preclinical research and from outpatient clinical trials suggest that treatment with amphetamine is efficacious in reducing cocaine intake. Although it has been suggested that amphetamine treatment reduces cocaine intake as an agonist replacement therapy, we have shown recently that multiple aspects of dopamine signaling are altered by cocaine self\u2010administration and returned to pre\u2010cocaine function by amphetamine treatment in the nucleus accumbens of male rats. Here, we sought to determine if these effects were also evident in female subjects, and across regions of the striatum. Female rats performed 5\u00a0days of cocaine self\u2010administration (1.5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0inj<jats:sup>\u22121<\/jats:sup>, 40\u00a0inj\/day) and were treated with a single amphetamine (0.56\u00a0mg\/kg) or saline infusion 1\u00a0hr prior to killing. We then used ex vivo fast\u2010scan cyclic voltammetry in the nucleus accumbens core or dorsolateral caudate\u2010putamen to examine dopamine signaling and cocaine potency. We found that in the nucleus accumbens core, cocaine self\u2010administration decreased dopamine uptake rate and cocaine potency, and both alterations were restored by amphetamine treatment. In the dorsolateral caudate\u2010putamen, neither cocaine self\u2010administration nor amphetamine treatment altered dopamine uptake; however, cocaine potency was decreased by self\u2010administration and returned to control levels by amphetamine. Together, these findings support a role for amphetamine treatment for cocaine addiction outside of agonist replacement therapy, and suggest that the development of cocaine tolerance is similar across sexes.<\/jats:p>","DOI":"10.1111\/ejn.14437","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T05:29:12Z","timestamp":1558416552000},"page":"2740-2749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modulation of striatal dopamine dynamics by cocaine self\u2010administration and amphetamine treatment in female rats"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-2089","authenticated-orcid":false,"given":"Cody A.","family":"Siciliano","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston\u2010Salem North Carolina"},{"name":"Department of Brain and Cognitive Sciences The 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