{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:27:46Z","timestamp":1774726066046,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gilles de la Tourette syndrome (\n                    <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>\n                    ) is a neurological condition characterized by motor and vocal tics. Previous studies suggested that this syndrome is associated with abnormal sensorimotor cortex activity at rest, as well as during the execution of voluntary movements. It has been hypothesized that this abnormality might be interpreted as a form of increased tonic inhibition, probably to suppress tics; however, this hypothesis has not been tested so far. The present study was designed to formally test how voluntary tic suppression in\n                    <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>\n                    influences the activity of the sensorimotor cortex during the execution of a motor task. We used\n                    <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                    to record neural activity over the contralateral sensorimotor cortex during a finger movement task in adult\n                    <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>\n                    patients, in both free ticcing and tic suppression conditions; these data were then compared with those collected during the same task in age\u2010matched healthy subjects. We focused on the levels of activity in the beta frequency band, which is typically associated with the activation of the motor system, during three different phases: a pre\u2010movement, a movement, and a post\u2010movement phase.\n                    <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>\n                    patients showed decreased levels of beta modulation with respect to the healthy controls, during the execution of the task; however, this abnormal pattern returned to be normal when they were explicitly asked to suppress their tics while moving. This is the first demonstration that voluntary tic suppression in\n                    <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>\n                    operates through the normalization of the\n                    <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                    rhythm in the beta frequency range during the execution of a voluntary finger movement.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14548","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T13:19:00Z","timestamp":1566047940000},"page":"3944-3957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Voluntary tic suppression and the normalization of motor cortical beta power in Gilles de la Tourette syndrome: an\n                    <scp>EEG<\/scp>\n                    study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-942X","authenticated-orcid":false,"given":"Laura","family":"Zapparoli","sequence":"first","affiliation":[{"name":"fMRI Unit IRCCS Istituto Ortopedico Galeazzi Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-2706","authenticated-orcid":false,"given":"Antonella","family":"Macerollo","sequence":"additional","affiliation":[{"name":"School of Psychology Faculty of Health and Life Sciences University of Liverpool Liverpool UK"},{"name":"The Walton Centre NHS Foundation Trust Fazakerley UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Institute of Neurology London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"},{"name":"Hotchkiss Brain Institute University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Kilner","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Institute of Neurology London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10401230600801077"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0164-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.16070141"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0976"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.02.015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0150-11.2011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.1051"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23186"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027850"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00202-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.08.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2014.09.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.2.184"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp299"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/026432998381005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.6.1216"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08838.2000"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2009.0118"},{"key":"e_1_2_10_23_1","first-page":"1","article-title":"Phenomenology of tics and natural history of tic disorders","volume":"85","author":"Leckman J. 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