{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:03:27Z","timestamp":1792476207041,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG BU 2621\/4\u20101"],"award-info":[{"award-number":["DFG BU 2621\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Neuroimaging studies provided evidence of altered gray matter volume (GMV) in FMS but, similarly, in chronic pain of other origin as well. Therefore, the purpose of this study was to evaluate the disease specificity of GMV alterations in FMS by direct comparison. Structural MRI data of the brain were acquired in 25 females with FMS and two different control groups: 21 healthy subjects and 23 patients with osteoarthritis. Regional GMVs were compared by voxel\u2010based morphometry and additional ROI\u2010analyses. In conclusion, we did not identify significant GMV alterations in either FMS or OA patients compared to healthy controls when adopting a conservative statistical approach with multiple comparison correction. However, even under a more liberal approach no FMS\u2010specific GMV changes were found because both pain groups presented increased gray matter volumes in the precentral gyrus and decreased GMV in the angular gyrus\/middle occipital gyrus and middle temporal gyrus in comparison with healthy controls. Since no differences between both pain groups could be detected cortical GMV changes in FMS should not be interpreted as FMS\u2010specific but might rather reflect changes in chronic pain in general. This previously held notion is confirmed in this study by direct comparison with a control group consisting of another pain disorder.<\/jats:p>","DOI":"10.1111\/ejn.14558","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T03:43:23Z","timestamp":1566791003000},"page":"3958-3967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Subtle changes of gray matter volume in fibromyalgia reflect chronic musculoskeletal pain rather than disease\u2010specific effects"],"prefix":"10.1111","volume":"50","author":[{"given":"Benedikt","family":"Sundermann","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology Medical Faculty \u2013 University of Muenster \u2013 and University Hospital Muenster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Dehghan Nayyeri","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Medical Faculty \u2013 University of Muenster \u2013 and University Hospital Muenster M\u00fcnster Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy LVR Clinic Medical Faculty of the Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Pfleiderer","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Medical Faculty \u2013 University of Muenster \u2013 and University Hospital Muenster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Stahlberg","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychotherapy University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"J\u00fcnke","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychotherapy University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Baie","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychotherapy University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Dieckmann","sequence":"additional","affiliation":[{"name":"Department of General Orthopaedics and Tumororthopaedics University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of General Orthopaedics and Tumororthopaedics University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Happe","sequence":"additional","affiliation":[{"name":"Orthopedic Surgeon M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-7702","authenticated-orcid":false,"given":"Markus","family":"Burgmer","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychotherapy University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541-04.2004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.11.014"},{"key":"e_1_2_11_5_1","article-title":"Region of interest analysis using an SPM toolbox [abstract] Presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2\u20106, 2002, Sendai, Japan","volume":"16","author":"Brett M.","year":"2002","journal-title":"NeuroImage"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02959944"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181a32da0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2011.00058.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0339-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.04.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.08.015"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1159"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"issue":"107","key":"e_1_2_11_15_1","first-page":"79","article-title":"The role of centralised pain in osteoarthritis","volume":"35","author":"Clauw D. 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