{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:32:48Z","timestamp":1792650768288,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Single\u2010housed stress elicits a range of social isolation\u2010related behavioral and neurobiological abnormalities. To investigate single housing\u2010induced behavioral changes and sex differences on stress outcomes, we examined single\u2010housed stress\u2010induced learning and memory impairment, depression\u2010like behaviors, neuroplasticity abnormalities and underlying mechanism. The results showed that male and female mice socially isolated for 8\u00a0weeks had significantly decreased memory acquisition, as demonstrated in the learning curve of the Morris water maze task. Memory consolidation and retrieval were also decreased in both the single\u2010housed male and female mice. These findings were corroborated further by the two classical animal models, Y\u2010maze and novel object recognition tests, as demonstrated by reduced spontaneous alternation and recognition index in both sexes of single\u2010housed mice. Subsequent studies suggested that single\u2010housed male mice exhibited increased immobility time in both the forced swim and tail suspension tests, while the female mice only exhibited increased immobility time in the tail suspension test. Moreover, single\u2010housed stress significantly decreased the apical and basal branch points, dendritic length, and spine density in the\n                    <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n                    1 of hippocampal neurons in both male and female mice. These effects were consistent with decreased neuroplasticity and neuroprotective\u2010related molecules such as synaptophysin,\n                    <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                    95,\n                    <jats:styled-content style=\"fixed-case\">PKA<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">pCREB<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>\n                    expression. These findings suggest that loss of neuronal remodeling and neuroprotective mechanisms due to single housing are involved in behavioral changes in both male and female mice. The results provide further evidence that neuroplasticity\u2010related signaling plays a crucial role in isolation\u2010induced effects on neuropsychiatric behavioral deficits in both sexes.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14565","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T08:54:37Z","timestamp":1567241677000},"page":"2694-2704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Single housing\u2010induced effects on cognitive impairment and depression\u2010like behavior in male and female mice involve neuroplasticity\u2010related signaling"],"prefix":"10.1111","volume":"52","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Department of Traditional Medical Orthopedics Honghui Hospital Xi'an Jiaotong University Xi'an, Shanxi China"},{"name":"Department of Pharmaceutical Sciences School of Pharmacy &amp; Pharmaceutical Sciences University at Buffalo, the State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-6649","authenticated-orcid":false,"given":"Yulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy &amp; Pharmaceutical Sciences University at Buffalo, the State University of New York Buffalo NY USA"},{"name":"College of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aerin Y.","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy &amp; Pharmaceutical Sciences University at Buffalo, the State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Banker","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy &amp; Pharmaceutical Sciences University at Buffalo, the State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hua","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy &amp; Pharmaceutical Sciences University at Buffalo, the State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.12.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.10.004"},{"issue":"3081","key":"e_1_2_9_4_1","first-page":"e3085","article-title":"Dissecting sholl analysis into its functional components","volume":"27","author":"Bird A. 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