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However, the pathways involved remain only partially determined with several cortical and brainstem structures implicated. This study examined the role of the dorsal reticular nucleus (\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    t) and infralimbic (\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    ) region of the medial prefrontal cortex in\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    . In vivo electrophysiology was performed to record from dorsal horn lamina V\/\n                    <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>\n                    wide dynamic range neurones with left hind paw receptive fields in anaesthetised sham\u2010operated and L5\/L6 spinal nerve\u2010ligated (\n                    <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>\n                    ) rats. Evoked neuronal responses were quantified in the presence and absence of a conditioning stimulus (left ear clamp). In sham rats,\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    were reproducibly recruited by a heterotopically applied conditioning stimulus, an effect that was absent in neuropathic rats. Intra\u2010\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    t naloxone had no effect on spinal neuronal responses to dynamic brush, punctate mechanical, evaporative cooling and heat stimuli in sham and\n                    <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>\n                    rats. In addition, intra\u2010\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    t naloxone blocked\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    in sham rats, but had no effect in\n                    <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>\n                    rats. Intra\u2010\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    lidocaine had no effect on spinal neuronal responses to dynamic brush, punctate mechanical, evaporative cooling and heat stimuli in sham and\n                    <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>\n                    rats. However, differential effects were observed in relation to the expression of\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    ; intra\u2010\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    lidocaine blocked activation of\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    in sham rats but restored\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">SNL<\/jats:styled-content>\n                    rats. These data suggest that the\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    is not directly involved in mediating\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    but can modulate its activation and that\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    t involvement in\n                    <jats:styled-content style=\"fixed-case\">DNIC<\/jats:styled-content>\n                    requires opioidergic signalling.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14576","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T12:38:30Z","timestamp":1568378310000},"page":"952-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A study of cortical and brainstem mechanisms of diffuse noxious inhibitory 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