{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:03:06Z","timestamp":1785495786896,"version":"3.56.0"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obsessive\u2013compulsive disorder (OCD) is a psychiatric illness that significantly impacts affected patients and available treatments yield suboptimal therapeutic response. Recently, the role of the gut\u2013brain axis (GBA) in psychiatric illness has emerged as a potential target for therapeutic exploration. However, studies concerning the role of the GBA in OCD are limited. To investigate whether a naturally occurring obsessive\u2013compulsive\u2010like phenotype in a rodent model, that is large nest building in deer mice, is associated with perturbations in the gut microbiome, we investigated and characterised the gut microbiota in specific\u2010pathogen\u2010free bred and housed large (LNB) and normal (NNB) nest\u2010building deer mice of both sexes (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011 per group, including three males and eight females). Following baseline characterisation of nest\u2010building behaviour, a single faecal sample was collected from each animal and the gut microbiota analysed. Our results reveal the overall microbial composition of LNB animals to be distinctly different compared to controls (PERMANOVA\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    .05). While no genera were found to be significantly differentially abundant after correcting for multiple comparisons, the normal phenotype showed a higher loading of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    and\n                    <jats:italic>Anaeroplasma<\/jats:italic>\n                    , while the OC phenotype demonstrated a higher loading of\n                    <jats:italic>Desulfovermiculus, Aestuariispira, Peptococcus<\/jats:italic>\n                    and\n                    <jats:italic>Holdemanella<\/jats:italic>\n                    (cut\u2010off threshold for loading at 0.2 in either the first or second component of the PCA). These findings not only provide proof\u2010of\u2010concept for continued investigation of the GBA in OCD, but also highlight a potential underlying aetiological association between alterations in the gut microbiota and the natural development of obsessive\u2013compulsive\u2010like behaviours.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14610","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:16:49Z","timestamp":1572394609000},"page":"1419-1427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Natural compulsive\u2010like behaviour in the deer mouse (\n                    <i>Peromyscus maniculatus bairdii<\/i>\n                    ) is associated with altered gut microbiota composition"],"prefix":"10.1111","volume":"51","author":[{"given":"Isabella M.","family":"Scheepers","sequence":"first","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North West\u2010University Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland University College Cork Cork Ireland"},{"name":"Department of Anatomy and Neuroscience University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomaz F. S.","family":"Bastiaanssen","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland University College Cork Cork Ireland"},{"name":"Department of Anatomy and Neuroscience University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Rea","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Clarke","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland University College Cork Cork Ireland"},{"name":"Department of Psychiatry and Neurobehavioural Science University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather B.","family":"Jaspan","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine (IDM) University of Cape Town Cape Town South Africa"},{"name":"Seattle Children\u2019s Research Institute University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North West\u2010University Potchefstroom South Africa"},{"name":"MRC Unit on Risk and Resilience in Mental Disorders University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian M. 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