{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:38:04Z","timestamp":1787877484435,"version":"build-2784847793"},"reference-count":111,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u00a0AG044402"],"award-info":[{"award-number":["T32\u00a0AG044402"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Identifying differential responses between sexes following traumatic brain injury (TBI) can elucidate the mechanisms behind disease pathology. Peripheral and central inflammation in the pathophysiology of TBI can increase sleep in male rodents, but this remains untested in females. We hypothesized that diffuse TBI would increase inflammation and sleep in males more so than in females. Diffuse TBI was induced in C57BL\/6J mice and serial blood samples were collected (baseline, 1, 5, 7\u00a0days post\u2010injury [DPI]) to quantify peripheral immune cell populations and sleep regulatory cytokines. Brains and spleens were harvested at 7DPI to quantify central and peripheral immune cells, respectively. Mixed\u2010effects regression models were used for data analysis. Female TBI mice had 77%\u2013124% higher IL\u20106 levels than male TBI mice at 1 and 5DPI, whereas IL\u20101\u03b2 and TNF\u2010\u03b1 levels were similar between sexes at all timepoints. Despite baseline sex differences in blood\u2010measured Ly6C\n                    <jats:sup>high<\/jats:sup>\n                    monocytes (females had 40% more than males), TBI reduced monocytes by 67% in TBI mice at 1DPI. Male TBI mice had 31%\u201333% more blood\u2010measured and 31% more spleen\u2010measured Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils than female TBI mice at 1 and 5DPI, and 7DPI, respectively. Compared with sham, TBI increased sleep in both sexes during the first light and dark cycles. Male TBI mice slept 11%\u201317% more than female TBI mice, depending on the cycle. Thus, sex and TBI interactions may alter the peripheral inflammation profile and sleep patterns, which might explain discrepancies in disease progression based on sex.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14611","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T06:19:27Z","timestamp":1572675567000},"page":"2791-2814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Acute peripheral inflammation and post\u2010traumatic sleep differ between sexes after experimental diffuse brain injury"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-3993","authenticated-orcid":false,"given":"Maha","family":"Saber","sequence":"first","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Giordano","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerin","family":"Hur","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Morrison","sequence":"additional","affiliation":[{"name":"College of Nursing University of Arizona Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Godbout","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Columbus OH USA"},{"name":"Center for Brain and Spinal Cord Repair The Ohio State University Columbus OH USA"},{"name":"Institute for Behavioral Medicine Research The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-8878","authenticated-orcid":false,"given":"Sean M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lifshitz","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"},{"name":"Phoenix Veteran Affairs Health Care System Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-3159","authenticated-orcid":false,"given":"Rachel K.","family":"Rowe","sequence":"additional","affiliation":[{"name":"BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA"},{"name":"Department of Child Health University of Arizona College of Medicine \u2013 Phoenix Phoenix AZ USA"},{"name":"Phoenix Veteran Affairs Health Care System Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-00857-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167605.02541.f2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181ba3354"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpi014"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00026"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v080.i01"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2018-017"},{"key":"e_1_2_11_9_1","volume-title":"Estimating multivariate models with brms","author":"B\u00fcrkner P. 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