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Recent research suggests that tDCS efficacy can be augmented using concurrent cognitive\u2010emotional training (CET). However, the neurophysiological changes associated with this combined intervention remain to be elucidated. We therefore examined the effects of tDCS combined with CET using electroencephalography (EEG). A total of 20 participants with treatment\u2010resistant depression took part in this open\u2010label study and received 18 sessions over 6\u00a0weeks of tDCS and concurrent CET. Resting\u2010state and task\u2010related EEG during a 3\u2010back working memory task were acquired at baseline and immediately following the treatment course. Results showed an improvement in mood and working memory accuracy, but not response time, following the intervention. We did not find significant effects of the intervention on resting\u2010state power spectral density (frontal theta and alpha asymmetry), time\u2013frequency power (alpha event\u2010related desynchronisation and theta event\u2010related synchronisation) or event\u2010related potentials (P2 and P3 components). We therefore identified little evidence of neurophysiological changes associated with treatment using tDCS and concurrent CET, despite significant improvements in mood and near\u2010transfer effects of cognitive training to working memory accuracy. Further research incorporating a sham\u2010controlled group may be necessary to identify the neurophysiological effects of the intervention.<\/jats:p>","DOI":"10.1111\/ejn.14656","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T05:35:55Z","timestamp":1576820155000},"page":"2119-2133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive\u2010emotional training for treatment\u2010resistant depression"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-9273","authenticated-orcid":false,"given":"Stevan","family":"Nikolin","sequence":"first","affiliation":[{"name":"School of Psychiatry University of New South Wales Sydney NSW Australia"},{"name":"Black Dog Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donel","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Psychiatry University of New South Wales Sydney NSW Australia"},{"name":"Black Dog Institute Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen K.","family":"Loo","sequence":"additional","affiliation":[{"name":"School of Psychiatry University of New South Wales Sydney NSW Australia"},{"name":"Black Dog Institute Sydney NSW Australia"},{"name":"St. George Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Iacoviello","sequence":"additional","affiliation":[{"name":"Click Therapeutics, Inc. 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