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Over time, different tests and models have been developed in rodents to study the anxiodepressive\u2010like consequences of chronic pain. This review describes these preclinical tools (models and tests) used for studying behavioural aspects of the comorbid relationship between chronic pain and anxiety and\/or major depressive disorder. Three major types of chronic pain strongly associated with anxiodepressive\u2010like comorbidity as well as their animal models are presented: neuropathic pain, inflammatory pain and fibromyalgia. After a description of chronic pain animal models and of the tests that allow determining nociceptive responses, this review presents and discusses the various behavioural tests that have been used to assess anxiety and depressive\u2010like behaviours in these models of chronic pain. Finally, this review highlights the progress that remains to be made to homogenize the results in the field of pain\u2010induced mood disorders and summarizes the recent advances achieved through these tests and models.<\/jats:p>","DOI":"10.1111\/ejn.14686","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T02:52:07Z","timestamp":1580093527000},"page":"236-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["How to study anxiety and depression in rodent models of chronic pain?"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-5706","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Kremer","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique Institut des Neurosciences Cellulaires et Int\u00e9gratives Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a J.","family":"Becker","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Institut des Neurosciences Cellulaires et Int\u00e9gratives Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Barrot","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Institut des Neurosciences Cellulaires et Int\u00e9gratives Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-8598","authenticated-orcid":false,"given":"Ipek","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Institut des Neurosciences Cellulaires et Int\u00e9gratives Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.0157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.06.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.033"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001372"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.02.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2017.03.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2011.07.012"},{"key":"e_1_2_10_9_1","first-page":"50978","article-title":"Marble burying and nestlet shredding as tests of repetitive, compulsive\u2010like behaviors in mice","volume":"82","author":"Angoa\u2010Perez M.","year":"2013","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.11.040"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.08.032"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.09.014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.528"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2477-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.041"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.01.019"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_10_22_1","first-page":"472","volume-title":"Principles of neural sciences","author":"Basbaum A. 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