{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:41:30Z","timestamp":1783122090481,"version":"3.54.6"},"reference-count":73,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Merck-Serono, Darmstadt, Germany."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Subtle executive function deficits, particularly regarding inhibitory control, have been reported in patients with phenylketonuria (PKU) despite early dietary treatment. Purpose of this study was to assess whether young female adults with PKU exhibit altered neural activity underlying such deficits, particularly in a fronto\u2010parietal cognitive control network (CCN). Behavioural data and functional magnetic resonance imaging (fMRI) data were acquired during a Go\u2010NoGo task in 16 young adult patients with PKU and 17 control subjects. Hypothesis\u2010driven analyses of behavioural and fMRI data in the CCN were supplemented by exploratory whole brain activation analyses. PKU patients exhibited a trend towards higher errors of commission. Patients exhibited marginally increased activation associated with inhibitory control in only one CCN core region (right middle frontal gyrus,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.043). Whole brain analyses revealed widespread relatively increased activation in adults with PKU in the main task contrast (NoGo\u00a0&gt;\u00a0Go). This increased activation was mainly observed outside the CCN and largely overlapped with the default mode network (DMN). In conclusion, only subtle inhibitory control deficits and associated brain activity differences were observed in young adults with PKU. Thus, this work adds to the notion that this particular population seems to be only slightly affected by such cognitive deficits. While there were also only minimal increases when compared to healthy subjects in brain activity in a cognitive control network, we observed more widespread activation increases outside this network. These results support the assumption of DMN dysfunction in PKU.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14738","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T08:56:05Z","timestamp":1586595365000},"page":"3951-3962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Approaching altered inhibitory control in phenylketonuria: A functional MRI study with a Go\u2010NoGo task in young female adults"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-3464","authenticated-orcid":false,"given":"Benedikt","family":"Sundermann","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology Medical Faculty \u2010 University of Muenster \u2010 and University Hospital Muenster Muenster 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