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Depletion of Fras1 in knockout mice results in sub\u2010epidermal blistering and fusion of eyelids and digits as well as malformation of lungs and kidneys. Mutations in the human counterpart\n                    <jats:italic>FRAS1<\/jats:italic>\n                    are responsible for the Fraser Syndrome with clinical manifestations similar to the murine phenotype. In addition, brain deformities or mental impairments have occasionally been reported in patients with Fraser Syndrome. In the present study, we explored the possible involvement of Fras1 in brain function, analysing its expression pattern in mouse brain and investigating aspects of\n                    <jats:italic>Fras1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice behaviour, related to the function of brain regions expressing\n                    <jats:italic>Fras1<\/jats:italic>\n                    . Transcripts were detected in choroid plexuses and in certain brain regions including cortical, hippocampal and amygdalar areas in juvenile mice. Behavioural tests revealed that\n                    <jats:italic>Fras1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibit impaired egocentric spatial memory, aberrant olfactory learning and memory, markedly reduced fear memory in an auditory fear conditioning task, as well as reduced anxiety expression in open field and elevated plus maze tests. Moreover, the extracellular matrix organization has been severely affected in cortical and subcortical areas as demonstrated by\n                    <jats:italic>Wisteria floribunda<\/jats:italic>\n                    agglutinin immunolabelling. The widespread detection of\n                    <jats:italic>Fras1<\/jats:italic>\n                    transcripts in the brain of both pre\u2010 and postnatal mice, as well as the behavioural and cellular disturbances exhibited by\n                    <jats:italic>Fras1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    adult mice provide evidence for the involvement of Fras1 in brain organization and function.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14759","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T15:34:22Z","timestamp":1587828862000},"page":"3905-3919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Behavioural effects of extracellular matrix protein Fras1 depletion in the 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