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Primarily affected by age, AD is the cause for old\u2010age dementia, progressive memory loss, dysfunctional thoughts, confusion, cognitive impairment and personality changes. Neuroglia formerly understood as \u201cglue\u201d of the brain neurons consists of macroglia (astrocytes and oligodendrocyte), microglia and progenitors NG2\u2010glia, and constitute a large fraction of the mammalian brain. The primary functions of glial cells are to provide neurons with metabolic and structural support in the healthy brain; however, they attain a \u201creactive\u201d state from the \u201cresting\u201d state upon challenged with a pathological insult such as a neurodegenerative cascade. Failure or defects in their homoeostatic functions (i.e. concentration of ions, neurotransmitters) ultimately jeopardize neurons with excitotoxicity and oxidative stress. Moreover, the most common clinical outcome of AD is the cognitive impairment and memory loss, which are attributed mainly by the accumulation of A\u03b2. Failure of glial cells to remove the A\u03b2 toxic proteins accelerates the AD progression. The rapidly emerging proteomic techniques such as mass spectrometry (MS), cross\u2010linking mass spectrometry, hydrogen deuterium trade mass spectrometry, protein foot printing and 2\u2010DGE combined with\u00a0LC\u2013MS\/MS present wide array of possibilities for the identification of differentially expressed proteins in AD.<\/jats:p>","DOI":"10.1111\/ejn.14838","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:36:07Z","timestamp":1590662167000},"page":"2931-2943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Neuron\u2010glia interactions: Molecular basis of alzheimer\u2019s disease and applications of neuroproteomics"],"prefix":"10.1111","volume":"52","author":[{"given":"Abdallah Mohammad","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Fundamentals of Nursing Department College of Nursing Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-7505","authenticated-orcid":false,"given":"Faheem Hyder","family":"Pottoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Clinical Pharmacy Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta Singh","family":"Dahiya","sequence":"additional","affiliation":[{"name":"National Institute of Stroke and Applied Neurosciences (NISAN) Auckland University of Technology Auckland New\u2010Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdos Alam","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Research Institute for Research and Medical Consultations Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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