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In normal conditions this activity is responsive to behavioural context, changing as an individual switches between directed tasks and task\u2010free conditions. A key feature of such changes is the movement of the brain between corresponding critical and sub\u2010critical states, with these dynamics supporting efficient cognitive processing. Breakdowns in processing efficiency can occur, however, in brain disorders such as depression. It was therefore hypothesised that depressive symptoms would be related to reduced intrinsic activity responsiveness to changes in behavioural state. This was tested in a mixed group of major depressive disorder patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a026) and healthy participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a037) by measuring intrinsic EEG activity temporal structure, quantified with detrended fluctuation analysis (DFA), in eyes\u2010closed (EC) and eyes\u2010open task\u2010free states and contrasting between the conditions. The degree to which DFA values changed between the states was found to correlate negatively with depressive symptoms. DFA values did not differ between states in those with higher symptom levels, meaning that the brain remained in a less flexible sub\u2010critical condition. This sub\u2010critical condition in the EC state was further found to correlate with levels of maladaptive rumination. This may reflect a general cognitive inflexibility resulting from a lack in neural activity reactivity that may predispose people to overly engage in self\u2010directed attention. These results provide an initial link between intrinsic activity reactivity and psychological features found in psychiatric disorders.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14858","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T21:15:16Z","timestamp":1591823716000},"page":"4840-4850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intrinsic activity temporal structure reactivity to behavioural state change is correlated with depressive symptoms"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-9119","authenticated-orcid":false,"given":"Niall W.","family":"Duncan","sequence":"first","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness Taipei Medical University Taipei Taiwan"},{"name":"Brain and Consciousness Research Centre TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-9114","authenticated-orcid":false,"given":"Tzu\u2010Yu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness Taipei Medical University Taipei Taiwan"},{"name":"Brain and Consciousness Research Centre TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Z.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness Taipei Medical University Taipei Taiwan"},{"name":"Brain and Consciousness Research Centre TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness Taipei Medical University Taipei Taiwan"},{"name":"Brain and Consciousness Research Centre TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Chien","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Psychiatry TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Lane","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind, Brain and Consciousness Taipei Medical University Taipei Taiwan"},{"name":"Brain and Consciousness Research Centre TMU Shuang\u2010Ho Hospital New Taipei City Taiwan"},{"name":"College of Humanities and Social Science Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.07.028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2017.09.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-35-11167.2003"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Being critical of criticality in the brain","volume":"3","author":"Beggs J. 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