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When neurons perform complex computations, such as processing stimulus\u2010related information or movement planning, it has been repeatedly shown, through measures such as the Fano factor (FF), that neural variability across trials decreases. However, multiple neurons contribute to a common computation on a single trial, rather than a single neuron contributing to a computation across multiple trials. Therefore, at the level of a single trial, the concept of FF loses significance. Here, using a combination of simulations and empirical data, we show that changes in the spiking regularity on single trials produce changes in FF. Further, at the behavioural level, the reaction time of the animal was faster when the neural spiking regularity both within and across trials was lower. Taken together, our results provide further constraints on how changes in spiking statistics help neurons optimally encode visual and saccade\u2010related information across multiple timescales and its implication on behaviour.<\/jats:p>","DOI":"10.1111\/ejn.14864","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T05:55:00Z","timestamp":1592286900000},"page":"4267-4282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessing within\u2010trial and across\u2010trial neural variability in macaque frontal eye fields and their relation to behaviour"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-890X","authenticated-orcid":false,"given":"Naveen","family":"Sendhilnathan","sequence":"first","affiliation":[{"name":"Department of Neuroscience Columbia University in the City of New York New York NY 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