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It is used to prevent or treat injuries of the central nervous system using different administration routes in different animal models. In this study, we evaluated whether intracisternal (IC) route for IGF\u20101 gene therapy may abrogate or at least reduce the structural and behavioral damages induced by the intraparenchymal injection of kainic acid (KA) into the rat spinal cord. Experimental (Rad\u2010IGF\u20101) and control (Rad\u2010DsRed\u2010KA) rats were evaluated using a battery of motor and sensory tests before the injection of the recombinant adenovector (day \u22123), before KA injection (day 0) and at every post\u2010injection (pi) time point (days 1, 2, 3 and 7 pi). Histopathological changes and neuronal and glial counting were assessed. Pretreatment using IC delivery of RAd\u2010IGF\u20101 improved animal's general condition and motor and sensory functions as compared to Rad\u2010DsRed\u2010KA\u2010injected rats. Besides, IC Rad\u2010IGF\u20101 therapy abrogated later spinal cord damage and reduced the glial response induced by KA as observed in Rad\u2010DsRed\u2010KA rats. We conclude that the IC route for delivering RAd\u2010IGF\u20101 prevents KA\u2010induced excitotoxicity in the spinal cord.<\/jats:p>","DOI":"10.1111\/ejn.14876","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T10:48:46Z","timestamp":1592909326000},"page":"3339-3352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intracisternal IGF\u20101 gene therapy abrogates kainic acid\u2010induced excitotoxic damage of the rat spinal cord"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-5605","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Nishida","sequence":"first","affiliation":[{"name":"Image Analysis Laboratory School of Veterinary Sciences National University of La Plata (UNLP) La Plata Argentina"},{"name":"National Research Council of Science and Technology (CONICET) Buenos Aires 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