{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:40:26Z","timestamp":1787830826397,"version":"build-2784847793"},"reference-count":92,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    By 2050, the global population of people aged 65\u00a0years or older will triple. While this is accompanied with an increasing burden of age\u2010associated diseases, it also emphasizes the need to understand the effects of healthy aging on cognitive processes. One such effect is a general slowing of processing speed, which is well documented in many domains. The execution of anti\u2010saccades depends on a well\u2010established brain\u2010wide network ranging from various cortical areas and basal ganglia through the superior colliculus down to the brainstem saccade generators. To clarify the consequences of healthy aging as well as gender on the execution of reflexive and voluntary saccades, we measured a large sample of healthy, non\u2010demented individuals (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0731, aged 51\u201384\u00a0years) in the anti\u2010saccade task. Age affected various aspects of saccade performance: The number of valid trials decreased with age. Error rate, saccadic reaction times (SRTs), and variability in saccade accuracy increased with age, whereas anti\u2010saccade costs, accuracy, and peak velocity of anti\u2010saccades and direction errors were not affected by age. Gender affected SRTs independent of age and saccade type with male participants having overall shorter SRTs. Our rigid and solid statistical testing using linear mixed\u2010effect models provide evidence for a uniform slowing of processing speed independent of the actually performed eye movement. Our data do not support the assumption of a specific deterioration of frontal lobe functions with aging.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14878","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T19:55:53Z","timestamp":1592942153000},"page":"4165-4184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The effect of age and gender on anti\u2010saccade performance: Results from a large cohort of healthy aging individuals"],"prefix":"10.1111","volume":"52","author":[{"given":"David J.","family":"Mack","sequence":"first","affiliation":[{"name":"Department of Cognitive Neurology Hertie Institute for Clinical Brain Research (HIH) University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research (HIH) University of T\u00fcbingen T\u00fcbingen 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Institute for Clinical Brain Research (HIH) University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lachenmaier","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research (HIH) University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Gugolz","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research (HIH) University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) T\u00fcbingen 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